Table 4 Diagnostic performance of US, radiomics signature, and nomogram for predicting lateral LN status in the training and validation cohorts
Cohorts | Sensitivity (%) | Specificity (%) | AUC (95%CI) | Accuracy (%) |
|---|---|---|---|---|
Training cohort | Â | Â | Â | Â |
US-reported lateral LN status in training cohort | 74.1 | 89.0 | 0.815 (0.716–0.915) | 87.6 |
Radiomics signature in training cohort | 77.8 | 90.1 | 0.908 (0.845–0.972) | 89.0 |
Radiomics nomogram in training cohort | 81.5 | 94.1 | 0.938 (0.887–0.989) | 93.0 |
Internal validation cohort | Â | Â | Â | Â |
US-reported lateral LN status in validation cohort | 73.3 | 90.6 | 0.820 (0.684–0.955) | 88.8 |
Radiomics signature in validation cohort 1 | 80.0 | 91.4 | 0.888 (0.786–0.990) | 90.2 |
Radiomics nomogram in validation cohort 1 | 86.7 | 92.2 | 0.905 (0.789–0.999) | 91.6 |
External validation cohort 1 | Â | Â | Â | Â |
US-reported lateral LN status in validation cohort 2 | 73.3 | 86.8 | 0.801 (0.665–0.936) | 85.4 |
Radiomics signature in validation cohort 2 | 66.7 | 82.9 | 0.796 (0.684–0.909) | 84.7 |
Radiomics nomogram in validation cohort 2 | 73.3 | 93.0 | 0.884 (0.785–0.984) | 90.9 |
External validation cohort 2 | Â | Â | Â | Â |
US-reported lateral LN status in validation cohort 3 | 73.7 | 86.8 | 0.803 (0.681–0.924) | 85.0 |
Radiomics signature in validation cohort 3 | 68.4 | 75.4 | 0.793 (0.683–0.903) | 74.4 |
Radiomics nomogram in validation cohort 3 | 78.9 | 89.5 | 0.906 (0.841–0.971) | 88.0 |