Table 3 The results of statistical analysis
Parameter | Patients, n | For OS | For PFS | ||
|---|---|---|---|---|---|
p-value, log-rank | Hazard ratio (CI 95%) | p-value, log-rank | Hazard ratio (CI 95%) | ||
PET/CT-parameters | |||||
SUVmax > 4 | 20/36 | 0.014 | 3.19 (1.2–8.48) | 0.002 | 3.01 (1.39–6.51) |
n, FLs ≥ 1 | 23/36 | 0.10 | 2.29 (0.83–6.32) | 0.08 | 1.86 (0.88–3.93) |
n, FLs > 3 | 15/36 | 0.003 | 3.7 (1.48–9.27) | < 0.001 | 5.54 (2.25–13.6) |
EMD Present versus not present | 12/36 | 0.004 | 3.40 (1.39–8.30) | 0.006 | 2.67 (1.23–5.83) |
n, FLs > 3 on CT only* | 28/36 | 0.74 | 1.19 (0.39–3.59) | 0.54 | 1.31 (0.53–3.22) |
Remission status | |||||
PR or worse versus at least vgPR | 21/36 | 0.327 | 1.58 (0.63–3.97) | 0.376 | 1.38 (0.67–2.83) |
Prior therapy lines | |||||
≥ 2 | 23/36 | 0.265 | 1.76 (0.64–4.87) | 0.128 | 1.84 (0.83–4.07) |
≥ 3 | 14/36 | 0.72 | 2.2 (0.91–5.4) | 0.001 | 3.6 (1.59–8.13) |
Clinical parameters | |||||
Age (≥ 65 years) | 11/36 | 0.169 | 1.86 (0.75–4.58) | 0.082 | 1.87 (0.86–4.07) |
Elevated LDH (> 250 U/l) | 20/36 | 0.006 | 3.86 (1.38–10.77) | 0.003 | 2.89 (1.35–6.17) |
ISS-Stage (I vs. II vs. III) | 19/13/4 | 0.016 | 2.37 (1.26–4.44) | 0.046 | 1.88 (1.09–3.24) |