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Table 2 Literature review and radiological data analysis

From: Imaging features of biliary adenofibroma of the liver with malignant transformation: a case report with literature review

Author/Year

Malignant transformation

Location

Number of lesions

Size(cm)

Shape

Margin

US

CT

MRI

Internal septa

Enhancement

Liver contour

Bile duct communication

Akin et al. [6]/2002

Yes

Subcapsular area of right lobe

Multiple

14

Lobulated

Obscure

—

—

—

Unilocular

Enhancement in arterial phase and early washout in portal phase

Protrusion

No

Garduño-López et al. [19]/2002

No

Subcapsular area of left lobe

Solitary

6

Lobulated

Well-defined

hypoechoic lesion

Solid-cystic mass

—

Multilocular

—

Protrusion

No

Varnholt et al. [20]/2003

No

Subcapsular area of left lobe

Solitary

16

Lobulated

—

cystic and solid mass with areas of increased echogenicity

Solid-cystic mass

—

Multilocular

—

Protrusion

No

Kai et al. [7]/2010

Yes

Subcapsular area of right lobe

Solitary

7

Lobulated

Well-defined

—

Multicystic mass lesion

—

Multilocular

Gradual enhancement

Protrusion

No

Tsutsui et al. [9]/2014

Yes

Subcapsular area of right lobe

Solitary

3.5

Lobulated

—

hyperechoic nodule with small hypoechoic

hypodense solid-cystic mass;

T1WI: low intensity; T2WI: high intensity and low intensity septa; DWI: markedly high intensity

Multilocular

One part: enhancement in arterial phase and early washout in portal phase; another part: early and prolonged enhancement

Protrusion

No

Jacobs et al. [10]/2015

Yes

Subcapsular area of right lobe

2

11.8

Lobulated

—

—

Heterogeneous, predominantly hypodense mass

—

Multilocular

—

Protrusion

No

Elpek et al. [32]/2016

No

—

Solitary

6

—

Well-defined

—

Multicystic mass lesion containing solid areas

—

Multilocular

—

—

—

Godambe et al. [11]/2016

Yes

Subcapsular area of left lobe

Solitary

6.3

—

—

—

—

—

Multilocular

Heterogeneous enhancement in arterial phase

—

—

Thai et al. [12]/2016

Yes

Subcapsular area of left lobe

Solitary

4

Targetoid

—

—

A targetoid lesion with a peripheral edematous halo and a necrotic central area

—

Unilocular

—

—

No

Thompson et al .[13]/2016

Yes

Subcapsular area of left lobe

Solitary

14.5

Lobulated

Well-defined

—

—

T2WI: heterogeneously increased signal; T1WI:isointensity to hypointensity

Multilocular

Enhancement in arterial phase and early washout in portal phase some regions: retention of contrast in delayed phase

Protrusion

No

Thompson et al.[13]/2016

Yes

Subcapsular area of caudate lobe

Solitary

6.6

Lobulated

Well-defined

—

—

T2WI: heterogeneously increased signal; DWI: restricted diffusion

Multilocular

Peripheral enhancement on delayed imaging

Protrusion

No

Kaminsky et al. [14]/2016

Yes

Subcapsular area of right lobe

Solitary

4.9

Lobulated

—

—

—

T1WI: hypointense, T2WI: heterogeneously hyperintense

Multilocular

Peripheral enhancement

Protrusion

No

Chua et al. [15]/2018

Yes

Subcapsular area of left lobe

Solitary

—

—

—

—

—

DWI: restricted diffusion

—

Enhancement in arterial phase and early washout and pseudocapsule formation in portal phase

—

—

Lee et al. [17]/2019

No

Subcapsular area of segments IV and VIII

Solitary

4.7

Lobulated

Well-defined

—

—

T1WI: low signal intensity; T2WI: bright signal intensity tumor with hypointense septa

Multilocular

Septal enhancement in delayed phase

Protrusion

No

Lee et al. [17]/2019

No

Subcapsular area of left lobe

Solitary

2.7

Lobulated

Well-defined

—

low attenuation

T1WI: hypointensity; T2WI: bright signal intensity

Multilocular

Septal and wall enhancement in portal venous phase

Protrusion

No

Sturm et al. [16]/2019

Yes

Subcapsular area of left lobe

Solitary

6.3

Lobulated

—

—

Solid-cystic mass

—

Multilocular

—

Protrusion

No

Present case /2021

Yes

Subcapsular area of right lobe

Solitary

1.8 cm

Irregular

Well-defined

hypoechoic subcapsular nodule

Hypodense solid-cystic mass

—

Unilocular

Enhancement in arterial phase and early washout in portal phase

Retraction

No