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Table 2 The ability of joint uptake ratio in detecting clinically active joint

From: Clinical utility of quantitative analysis of bone scintigraphy in detecting clinically active joint and high disease activity in patients with rheumatoid arthritis

Joint

AUC (95% CI)

Cut-off joint uptake ratio

Sensitivity (%) (95% CI)

Specificity (%) (95% CI)

PPV (%) (95% CI)

NPV (%) (95% CI)

Shoulder (n = 130)

0.638 (0.527–0.751)

1.47

81.8 (59.7–94.8)

46.3 (36.7–56.2)

23.7 (19.3–28.8)

92.6 (83.4–96.9)

Elbow (n = 129)

0.852 (0.754–0.925)

1.31

75.0 (50.9–91.3)

83.5 (75.2–89.9)

45.5 (33.7–55.7)

94.8 (89.5–97.5)

Wrist (n = 130)

0.906 (0.843–0.950)

1.86

93.2 (84.9–97.8)

78.6 (65.6–88.4)

85.2 (77.6–90.5)

89.8 (78.9–95.4)

MCP (n = 650)

0.812 (0.754–0.857)

1.23

81.3 (71.8–88.7)

62.1 (57.9–66.1)

25.9 (23.2–28.7)

95.3 (93.0–96.9)

Hand IP (n = 650)

0.688 (0.641–0.740)

0.90

76.0 (68.9–82.2)

47.4 (42.8–52.0)

34.0 (31.4–36.8)

84.7 (80.7–88.0)

Knee (n = 128)

0.782 (0.678–0.863)

1.37

85.0 (70.2–94.3)

61.4 (50.4–71.6)

50.0 (42.7–57.3)

90.0 (80.9–95.0)

Total (n = 1817)

0.752 (0.724–0.778)

1.07

78.7 (74.5–82.5)

52.0 (49.4–54.7)

32.9 (31.3–34.6)

89.1 (87.1–90.8)

  1. AUC, area under the receiver operating characteristic curve; CI, confidence interval; IP, interphalangeal; MCP, metacarpo-phalangeal; NPV, negative predictive value; PPV, positive predictive value