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Table 4 The detailed information of the features

From: Prediction of BRCA gene mutation status in epithelial ovarian cancer by radiomics models based on 2D and 3D CT images

Image type Features Features explanation
X3D-venous-wavelet.LHH Glcm–cluster shade \(\mathop \sum \limits_{i = 1}^{{N_{g} }} \mathop \sum \limits_{j = 1}^{{N_{g} }} \left( {i + j - \mu_{x} - \mu_{y} } \right)^{3} p\left( {i,j} \right)\) Cluster Shade is a measure of the skewness and uniformity of the GLCM. A higher cluster shade implies greater asymmetry about the mean
X3D-venous-wavelet.HHH Firstorder –mean absolute deviation (MAD)\(\frac{1}{{N_{p} }}\mathop \sum \limits_{i = 1}^{{N_{p} }} \left| {X\left( i \right) - X } \right|\) Mean Absolute Deviation is the mean distance of all intensity values from the Mean Value of the image array
X2D-venous-wavelet.HLH X2D-delay-wavelet.LHHX2D-Artery-wavelet.HHH Firstorder—skewness \(\frac{{\mu_{3} }}{{\sigma^{3} }} = \frac{{\frac{1}{{N_{p} }}\mathop \sum \nolimits_{i = 1}^{{N_{p} }} \left( {X\left( i \right) - X} \right)^{3} }}{{\left( {\sqrt {\frac{1}{{N_{p} }}} \sqrt {\mathop \sum \nolimits_{i = 1}^{{N_{p} }} \left( {X\left( i \right) - X} \right)^{2} } } \right)^{3} }}\) Skewness measures the asymmetry of the distribution of values about the Mean value. Depending on where the tail is elongated and the mass of the distribution is concentrated, this value can be positive or negative
X3D-delay-wavelet.LHH Glcm—IDMN \(\mathop \sum \limits_{k = 0}^{{N_{g} - 1}} \frac{{P_{x - y} \left( k \right)}}{{1 + \left( {\frac{{k^{2} }}{{N_{g}^{2} }}} \right)}}\) IDMN (inverse difference moment normalized) is a measure of the local homogeneity of an image. IDMN weights are the inverse of the Contrast weights (decreasing exponentially from the diagonal i = ji = j in the GLCM). Unlike Homogeneity2, IDMN normalizes the square of the difference between neighboring intensity values by dividing over the square of the total number of discrete intensity values
X2D-venous Original shape elongnation \(\sqrt {\frac{{\lambda_{minor} }}{{\lambda_{major} }}}\) Elongation shows the relationship between the two largest principal components in the ROI shape. For computational reasons, this feature is defined as the inverse of true elongation
X2D-venous-wavelet.HHH Glszm–Zone entropy (ZE)\(- \mathop \sum \limits_{i = 1}^{{N_{g} }} \mathop \sum \limits_{j = 1}^{{N_{s} }} p\left( {i,j} \right)\log_{2} \left( {p\left( {i,j} \right) + \in } \right)\) ZE measures the uncertainty/randomness in the distribution of zone sizes and gray levels. A higher value indicates more heterogeneneity in the texture patterns
X2D-venous-wavelet.HHH Glszm–gray level non-uniformity (GLN)\(\frac{{\mathop \sum \nolimits_{i = 1}^{{N_{g} }} \left( {\mathop \sum \nolimits_{j = 1}^{{N_{s} }} P\left( {i,j} \right)} \right)^{2} }}{{N_{z} }}\) GLN measures the variability of gray-level intensity values in the image, with a lower value indicating more homogeneity in intensity values
X3D-artery-wavelet.HLL Firstorder—Kurtosis \(\frac{{\mu _{4} }}{{\sigma ^{4} }} = \frac{{\frac{1}{{{\text{N}}_{{\text{p}}} }}\sum\nolimits_{{{\text{i}} = 1}}^{{{\text{N}}_{{\text{p}}} }} {\left( {{\text{X}}\left( {\text{i}} \right) - {\text{X}}} \right)^{4} } }}{{\left( {\frac{1}{{{\text{N}}_{{\text{p}}} }}\sum\nolimits_{{{\text{i}} = 1}}^{{{\text{N}}_{{\text{p}}} }} {\left( {{\text{X}}\left( {\text{i}} \right) - {\text{X}}} \right)^{2} } } \right)^{2} }}\) Kurtosis is a measure of the ‘peakedness’ of the distribution of values in the image ROI. A higher kurtosis implies that the mass of the distribution is concentrated towards the tail(s) rather than towards the mean. A lower kurtosis implies the reverse: that the mass of the distribution is concentrated towards a spike near the Mean value
X2D-delay-wavelet.HHH Glszm–small area high gray level emphasis (SAHGLE)\(\frac{{\mathop \sum \nolimits_{i = 1}^{{N_{g} }} \mathop \sum \nolimits_{j = 1}^{{N_{s} }} \frac{{P\left( {i,j} \right)i^{2} }}{{j^{2} }}}}{{N_{z} }}\) SAHGLE measures the proportion in the image of the joint distribution of smaller size zones with higher gray-level values
X2D-venous-wavelet.LLL Firstorder–range max(X)-min(X) The range of gray values in the ROI