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Table 4 Univariate logistic regression analysis of MRI findings and effect of neoadjuvant chemotherapy

From: Predicting pathologic response to neoadjuvant chemotherapy in patients with locally advanced breast cancer using multiparametric MRI

Variable Univariate analysis
OR 95% CI P value
Breast type    
 Fibrous gland 0.682 0.085–5.448 0.718
 Compact 0.795 0.125–5.045 0.808
 Unknown Ref   
Lesion types    
 Irregular 0.182 0.027–1.243 0.082
 Section distribution Ref   
 Circular 0.600 0.070–5.136 0.641
 Satellite lesions 0.250 0.027–2.319 0.223
Lesion location    
 Left 0.217 0.051–0.936 0.040
 Right Ref   
Lesion quadrant    
 Outer quadrant 0.182 0.027–1.243 0.082
 Upper inner 0.600 0.070–5.136 0.641
 Central Ref   
 Diffuse 0.250 0.027–2.319 0.223
BI-RADS rating    
 5 1.667 0.306–9.080 0.555
 6 Ref   
 Unknown 5.000 0.212–117.894 0.318
Pectoral muscle invasive    
 Yes 2.037 0.383–10.845 0.404
 No Ref   
Skin around areola invasive    
 Yes 2.692 0.713–10.170 0.144
 No Ref   
Crater nipple    
 Yes 3.636 0.699–18.918 0.125
 No Ref   
Internal mammary artery thickening    
 Yes 1.095 0.293–4.097 0.892
 No Ref   
Subareolar duct invasive    
 Yes 3.636 0.699–18.918 0.125
 No Ref   
Contralateral breast    
 Hyperplasia and adenosis 6.158 0.694–54.644 0.103
 Galactocele/fortified nodule Ref   
 No 4.333 0.326–57.649 0.267
Standard ADC change*    
 ≤ 15% 9.9 1.16–84.471 0.036
 > 15% Ref   
Tumor size change*    
 ≤ 15% 0.156 0.018–1.339 0.090
 > 15% Ref   
Slow ADC change*    
 ≤ 15% 3.75 0.714–19.707 0.118
 > 15% Ref   
TIC ype    
 Ascending 0.400 0.036–4.411 0.454
 Reduced Ref   
 Invariable 0.522 0.129–2.116 0.362
  1. MRI data are measured at baseline
  2. ADC apparent diffusion coefficient, TIC time intensity curve
  3. *Data are measured at the first two cycles