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Table 4 Univariate logistic regression analysis of MRI findings and effect of neoadjuvant chemotherapy

From: Predicting pathologic response to neoadjuvant chemotherapy in patients with locally advanced breast cancer using multiparametric MRI

Variable

Univariate analysis

OR

95% CI

P value

Breast type

   

 Fibrous gland

0.682

0.085–5.448

0.718

 Compact

0.795

0.125–5.045

0.808

 Unknown

Ref

  

Lesion types

   

 Irregular

0.182

0.027–1.243

0.082

 Section distribution

Ref

  

 Circular

0.600

0.070–5.136

0.641

 Satellite lesions

0.250

0.027–2.319

0.223

Lesion location

   

 Left

0.217

0.051–0.936

0.040

 Right

Ref

  

Lesion quadrant

   

 Outer quadrant

0.182

0.027–1.243

0.082

 Upper inner

0.600

0.070–5.136

0.641

 Central

Ref

  

 Diffuse

0.250

0.027–2.319

0.223

BI-RADS rating

   

 5

1.667

0.306–9.080

0.555

 6

Ref

  

 Unknown

5.000

0.212–117.894

0.318

Pectoral muscle invasive

   

 Yes

2.037

0.383–10.845

0.404

 No

Ref

  

Skin around areola invasive

   

 Yes

2.692

0.713–10.170

0.144

 No

Ref

  

Crater nipple

   

 Yes

3.636

0.699–18.918

0.125

 No

Ref

  

Internal mammary artery thickening

   

 Yes

1.095

0.293–4.097

0.892

 No

Ref

  

Subareolar duct invasive

   

 Yes

3.636

0.699–18.918

0.125

 No

Ref

  

Contralateral breast

   

 Hyperplasia and adenosis

6.158

0.694–54.644

0.103

 Galactocele/fortified nodule

Ref

  

 No

4.333

0.326–57.649

0.267

Standard ADC change*

   

 ≤ 15%

9.9

1.16–84.471

0.036

 > 15%

Ref

  

Tumor size change*

   

 ≤ 15%

0.156

0.018–1.339

0.090

 > 15%

Ref

  

Slow ADC change*

   

 ≤ 15%

3.75

0.714–19.707

0.118

 > 15%

Ref

  

TIC ype

   

 Ascending

0.400

0.036–4.411

0.454

 Reduced

Ref

  

 Invariable

0.522

0.129–2.116

0.362

  1. MRI data are measured at baseline
  2. ADC apparent diffusion coefficient, TIC time intensity curve
  3. *Data are measured at the first two cycles