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Table 3 Analysis of associations between MRI findings and effect of neoadjuvant chemotherapy

From: Predicting pathologic response to neoadjuvant chemotherapy in patients with locally advanced breast cancer using multiparametric MRI

Variable All, n (%) pCR, n (%) Non-pCR, n (%) P value
Breast type     
 Fibrous gland 14 (28.0) 3 (25.0) 9 (23.7)  
 Compact 30 (60.0) 7 (58.3) 5 (13.2)  
 Unknown 6 2 4 0.936
Lesion types     
 Irregular 26 (52.0) 4 (33.3) 22 (57.9)  
 Section distribution 6 (12.0) 3 (25.0) 3 (7.9)  
 Circular 8 (16.0) 3 (25.0) 5 (13.2)  
 Satellite lesions 10 (20.0) 2 (16.7) 8 (21.1) 0.244
Lesion location     
 Left 24 (48.0) 9 (75.0) 15 (39.5)  
 Right 26 (52.0) 3 (25.0) 23 (60.5) 0.032
Lesion quadrant     
 Outer quadrant 37 (74.0) 9 (75.0) 28 (73.7)  
 Upper inner 7 (14.0) 1 (8.3) 6 (15.8)  
 Central 5 (10.0) 1 (8.3) 4 (10.5)  
 Diffuse 5 (10.0) 1 (8.3) 4 (10.5) 0.886
BI-RADS rating     
 5 39 (78.0) 9 (75.0) 30 (78.9)  
 6 8 (16.0) 2 (16.7) 6 (15.8)  
 Unknown 3 1 2 0.573
Pectoral muscle invasive     
 Yes 13 (26.0) 10 (83.3) 3 (7.9)  
 No 37 (74.0) 2 (16.7) 35 (92.1) 0.398
Skin around areola invasive     
 Yes 30 (60.0) 5 (41.7) 25 (65.8)  
 No 20 (40.0) 7 (58.3) 13 (34.2) 0.137
Crater nipple     
 Yes 18 (36.0) 2 (16.7) 16 (42.1)  
 No 32 (64.0) 10 (83.3) 22 (57.9) 0.109
Internal mammary artery thickening     
 Yes 30 (60.0) 7 (58.3) 23 (60.5)  
 No 20 (40.0) 5 (41.7) 15 (39.5) 0.892
Subareolar duct invasive     
 Yes 18 (36.0) 3 (25.0) 15 (39.5)  
 No 32 (64.0) 9 (75.0) 24 (63.2) 0.109
Contralateral breast     
 Hyperplasia and adenosis 30 (60.0) 9 (75.0) 21 (55.3)  
 Galactocele/fortified nodule 14 (28.0) 1 (8.3) 12 (31.6)  
 No 8 (16.0) 2 (16.7) 6 (15.8) 0.202
Standard ADC change*     
 ≤ 15% 19 (38.0) 1 (18.3) 18 (47.4)  
 > 15% 31 (62.0) 11 (91.7) 20 (52.6) 0.015
Slow ADC change*     
 ≤ 15% 17 (36.2) 2 (16.7) 15 (42.9)  
 > 15% 30 (63.8) 10 (83.3) 20 (57.1) 0.103
 Unknown 3 1 2  
Tumor size change*     
 ≤ 15% 15 (30.0) 1 (8.3) 14 (36.8) 0.06
 > 15% 35 (70.0) 11 (91.7) 24 (63.2) 0
Fast ADC (10−3 mm2/s)     
 Value 15.0 ± 14.4 13.9 ± 17.9 15.3 ± 13.1 0.785
 Unknown 6 1 5  
F value (%)     
 Value 40.3 ± 27.8 47.3 ± 30.7 38.0 ± 26.9  
 Unknown 5 1 4 0.337
TIC type     
 Ascending 6 (12.0) 1 (8.3) 5 (13.2)  
 Reduced 15 (30.0) 5 (41.7) 10 (26.3)  
 Invariable 29 (58.0) 6 (50.0) 23 (60.5) 0.586
  1. MRI data are measured at baseline
  2. ADC apparent diffusion coefficient, TIC time intensity curve, F value fraction of fast ADC
  3. *Data are measured at the first two cycles