Reliability of the freehand region-of-interest method in quantitative cerebral diffusion tensor imaging

Hakulinen, Ullamari; Brander, Antti; Ilvesmäki, Tero; Helminen, Mika; Öhman, Juha; Luoto, Teemu M.; Eskola, Hannu

doi:10.1186/s12880-021-00663-8

BMC Medical Imaging

Table 3 Inter-observer regional mean FA (0-1, unitless), ADC (10⁻³ mm²/s), AD (10⁻³ mm²/s) and RD (10⁻³ mm²/s) values ± standard deviation (mean ± SD) values, variation (the percent coefficients of variation = CV%) and repeatability (mean difference ± 2SD) (observer 1 & 2) (N = 15)

From: Reliability of the freehand region-of-interest method in quantitative cerebral diffusion tensor imaging

Region		Obs. 1	Obs. 2	Obs. 1	Obs. 2	Obs.1 and Obs. 2
Region		Mean ± SD	Mean ± SD	CV(%)	CV(%)	Mean diff ± 2SD
Cerebral peduncle	FA	0.817 ± 0.039	0.818 ± 0.033	4.8	4.1	− 0.001 ± 0.057
	ADC	0.731 ± 0.049	0.721 ± 0.051	6.7	7.1	0.010 ± 0.072
	AD	1.652 ± 0.115	1.632 ± 0.113	7.0	6.9	0.021 ± 0.139
	RD	0.271 ± 0.052	0.270 ± 0.048	19.2	17.7	0.000 ± 0.065
Internal capsule (posterior)	FA	0.707 ± 0.027	0.719 ± 0.040	3.8	5.6	− 0.012 ± 0.053
	ADC	0.709 ± 0.025	0.711 ± 0.028	3.5	4.0	− 0.002 ± 0.031
	AD	1.403 ± 0.043	1.435 ± 0.064	3.1	4.5	− 0.033 ± 0.101
	RD	0.360 ± 0.030	0.346 ± 0.040	8.3	11.5	0.014 ± 0.044
Corona radiata	FA	0.524 ± 0.049	0.522 ± 0.050	9.3	9.6	0.002 ± 0.049
	ADC	0.683 ± 0.038	0.686 ± 0.043	5.5	6.3	− 0.003 ± 0.028
	AD	1.099 ± 0.049	1.108 ± 0.055	4.4	5.0	− 0.008 ± 0.069
	RD	0.475 ± 0.052	0.477 ± 0.056	10.9	11.7	− 0.002 ± 0.036
Centrum semiovale	FA	0.571 ± 0.080	0.579 ± 0.054	14.1	9.3	− 0.008 ± 0.133
	ADC	0.716 ± 0.029	0.708 ± 0.035	4.1	4.9	0.009 ± 0.033
	AD	1.238 ± 0.082	1.299 ± 0.046	6.6	3.7	0.010 ± 0.182
	RD	0.456 ± 0.064	0.447 ± 0.051	14.1	11.3	0.009 ± 0.080
Uncinate fasciculus	FA	0.595 ± 0.057	0.562 ± 0.054	9.6	9.6	0.033 ± 0.033
	ADC	0.789 ± 0.050	0.786 ± 0.041	6.3	5.2	0.003 ± 0.043
	AD	1.403 ± 0.069	1.348 ± 0.065	4.9	4.9	0.054 ± 0.089
	RD	0.482 ± 0.065	0.505 ± 0.057	13.5	11.3	− 0.023 ± 0.035
Forceps minor	FA	0.529 ± 0.072	0.494 ± 0.069	13.5	14	0.034 ± 0.113
	ADC	0.768 ± 0.037	0.771 ± 0.044	4.8	5.7	− 0.002 ± 0.051
	AD	1.275 ± 0.073	1.234 ± 0.063	5.7	5.1	0.041 ± 0.126
	RD	0.515 ± 0.064	0.539 ± 0.066	12.5	12.3	− 0.024 ± 0.093
Thalamus	FA	0.322 ± 0.031	0.315 ± 0.027	9.5	8.5	0.006 ± 0.050
	ADC	0.755 ± 0.028	0.750 ± 0.028	3.7	3.8	0.005 ± 0.018
	AD	1.005 ± 0.031	0.992 ± 0.024	3.1	2.5	0.012 ± 0.054
	RD	0.630 ± 0.034	0.629 ± 0.033	5.4	5.3	0.001 ± 0.028
CC Genu	FA	0.868 ± 0.042	0.849 ± 0.057	4.8	6.7	0.019 ± 0.064
	ADC	0.745 ± 0.047	0.760 ± 0.055	6.3	7.2	− 0.015 ± 0.085
	AD	1.808 ± 0.093	1.799 ± 0.109	5.2	6.0	0.009 ± 0.186
	RD	0.213 ± 0.062	0.240 ± 0.081	29.1	33.7	− 0.026 ± 0.086
CC Splenium	FA	0.868 ± 0.050	0.862 ± 0.054	5.7	6.2	0.006 ± 0.092
	ADC	0.733 ± 0.067	0.749 ± 0.053	9.2	6.2	− 0.017 ± 0.098
	AD	1.778 ± 0.140	1.805 ± 0.112	7.9	6.2	− 0.027 ± 0.136
	RD	0.210 ± 0.074	0.222 ± 0.076	35.2	34.4	− 0.011 ± 0.136

FA, fractional anisotropy; ADC, apparent diffusion coefficient; AD, axial diffusivity; RD, radial diffusivity
CV, coefficient of variation; CC, corpus callosum; diff, difference; SD, standard deviation

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