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Table 2 The intra-observer (observer 1) regional mean FA (0–1, unitless), ADC (10−3 mm2/s), AD (10−3 mm2/s) and RD (10−3 mm2/s) values ± standard deviation (mean ± SD), variation (the percent coefficients of variation = CV%) and repeatability (the intra-class correlation coefficients (ICC) and mean difference ± 2SD) (N = 40)

From: Reliability of the freehand region-of-interest method in quantitative cerebral diffusion tensor imaging

Region

 

1st meas

2nd meas

1st meas

2nd meas

Average

Single

1st and 2st meas

Mean ± SD

Mean ± SD

CV (%)

CV (%)

ICC

ICC

Mean diff ± 2SD

Cerebral peduncle

FA

0.808 ± 0.041

0.804 ± 0.044

5.0

5.5

0.748

0.597

0.004 ± 0.077

ADC

0.727 ± 0.045a

0.725 ± 0.051

6.2

7.0

0.801

0.668

0.002 ± 0.079

AD

1.625 ± 0.106b

1.614 ± 0.122

6.5

7.6

0.859

0.752

0.010 ± 0.161

RD

0.278 ± 0.051

0.280 ± 0.053

18.3

19.0

0.756

0.608

 − 0.003 ± 0.093

Internal capsule (posterior)

FA

0.699 ± 0.033c

0.689 ± 0.037

4.7

5.3

0.859

0.752

0.010 ± 0.046

ADC

0.706 ± 0.021d

0.702 ± 0.021

3.0

3.0

0.949

0.903

0.003 ± 0.018

AD

1.388 ± 0.053

1.371 ± 0.055

3.8

4.0

0.877

0.781

0.018 ± 0.065

RD

0.364 ± 0.030e

0.368 ± 0.034

8.2

9.2

0.912

0.839

 − 0.004 ± 0.036

Corona radiata

FA

0.502 ± 0.049f

0.491 ± 0.047

9.7

9.6

0.867

0.766

0.011 ± 0.063

ADC

0.700 ± 0.035g

0.708 ± 0.034

5.0

4.8

0.936

0.880

 − 0.008 ± 0.030

AD

1.104 ± 0.050

1.105 ± 0.048

4.5

4.3

0.848

0.736

 − 0.001 ± 0.071

RD

0.498 ± 0.048h

0.510 ± 0.050

9.7

9.8

0.917

0.846

 − 0.012 ± 0.051

Centrum semiovale

FA

0.542 ± 0.067

0.549 ± 0.060

12.3

11

0.894

0.809

 − 0.007 ± 0.078

ADC

0.724 ± 0.030i

0.724 ± 0.029

4.2

4.0

0.976

0.953

0.000 ± 0.018

AD

1.210 ± 0.066

1.217 ± 0.049

5.5

4.0

0.764

0.618

 − 0.008 ± 0.102

RD

0.481 ± 0.056

0.477 ± 0.052

11.7

11

0.938

0.882

0.004 ± 0.053

Uncinate fasciculus

FA

0.566 ± 0.060j

0.566 ± 0.056

10.6

9.9

0.945

0.895

 − 0.001 ± 0.054

ADC

0.784 ± 0.042

0.785 ± 0.041

5.3

5.3

0.954

0.912

 − 0.001 ± 0.035

AD

1.351 ± 0.078

1.355 ± 0.063

5.8

4.6

0.882

0.789

 − 0.004 ± 0.093

RD

0.500 ± 0.053

0.500 ± 0.059

10.5

11.8

0.963

0.929

0.000 ± 0.045

Forceps minor

FA

0.505 ± 0.058k

0.505 ± 0.054

11.5

10.6

0.933

0.874

0.001 ± 0.057

ADC

0.771 ± 0.033

0.768 ± 0.034

4.3

4.5

0.940

0.887

0.003 ± 0.032

AD

1.246 ± 0.071

1.240 ± 0.063

5.7

5.0

0.893

0.807

0.006 ± 0.084

RD

0.533 ± 0.044

0.530 ± 0.053

8.3

10

0.946

0.897

0.003 ± 0.048

Thalamus

FA

0.316 ± 0.026

0.311 ± 0.028

8.3

9.2

0.862

0.758

0.005 ± 0.037

ADC

0.758 ± 0.027

0.760 ± 0.027

3.5

3.5

0.960

0.924

 − 0.001 ± 0.021

AD

1.004 ± 0.033

1.001 ± 0.035

3.2

3.5

0.914

0.842

0.003 ± 0.038

RD

0.635 ± 0.032

0.640 ± 0.029

5.0

4.5

0.917

0.847

 − 0.004 ± 0.032

CC Genu

FA

0.861 ± 0.040

0.864 ± 0.045

4.6

5.3

0.855

0.747

 − 0.002 ± 0.061

ADC

0.757 ± 0.045

0.759 ± 0.047

6.0

6.2

0.829

0.708

 − 0.001 ± 0.071

AD

1.822 ± 0.100

1.831 ± 0.101

5.5

5.5

0.886

0.796

 − 0.010 ± 0.129

RD

0.225 ± 0.057

0.222 ± 0.064

25.4

28.7

0.857

0.750

0.003 ± 0.086

CC Splenium

FA

0.853 ± 0.043

0.847 ± 0.041

5.0

4.8

0.877

0.781

0.006 ± 0.055

ADC

0.741 ± 0.057

0.748 ± 0.062

7.8

8.3

0.921

0.854

 − 0.007 ± 0.064

AD

1.768 ± 0.131

1.766 ± 0.138

7.4

7.8

0.942

0.891

0.001 ± 0.127

RD

0.230 ± 0.060

0.238 ± 0.058

26.1

24.4

0.861

0.756

 − 0.009 ± 0.082

  1. FA, fractional anisotropy; ADC, apparent diffusion coefficient; AD, axial diffusivity; RD, radial diffusivity; ICC, intraclass correlation coefficient; CV, coefficient of variation; CC, corpus callosum; diff, difference; SD, standard deviation
  2. Regions with significant differences between right (R) and left (L) cerebral hemispheres (p < 0.007):
  3. a,bCerebral peduncle (a) ADC: R 0.746 ± 0.062, L 0.707 ± 0.060 (b) AD: R 1.660 ± 0.138 L 1.592 ± 0.122;
  4. c,d,ePosterior limb of the Internal capsule: (c) FA: R 0.693 ± 0.037, L 0.707 ± 0.036 d) ADC: R 0.713 ± 0.025, L 0.698 ± 0.024
  5. (e) RD: R 0.373 ± 0.037, L 0.355 ± 0.031; (f,g,h) Corona radiata: (f) FA: R 0.693 ± 0.037, L 0.707 ± 0.036
  6. (g) ADC: R 0.713 ± 0.025, L 0.698 ± 0.024 (h) RD: R 0.373 ± 0.037, L 0.355 ± 0.031
  7. iCentrum Semiovale (i) ADC: R 0.731 ± 0.034, L 0.717 ± 0.032, jUncinate fasciculus (j) FA: R 0.575 ± 0.062, L 0.556 ± 0.064
  8. kForceps minor (k) FA: R 0.519 ± 0.070, L 0.491 ± 0.058