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Table 2 The intra-observer (observer 1) regional mean FA (0–1, unitless), ADC (10−3 mm2/s), AD (10−3 mm2/s) and RD (10−3 mm2/s) values ± standard deviation (mean ± SD), variation (the percent coefficients of variation = CV%) and repeatability (the intra-class correlation coefficients (ICC) and mean difference ± 2SD) (N = 40)

From: Reliability of the freehand region-of-interest method in quantitative cerebral diffusion tensor imaging

Region   1st meas 2nd meas 1st meas 2nd meas Average Single 1st and 2st meas
Mean ± SD Mean ± SD CV (%) CV (%) ICC ICC Mean diff ± 2SD
Cerebral peduncle FA 0.808 ± 0.041 0.804 ± 0.044 5.0 5.5 0.748 0.597 0.004 ± 0.077
ADC 0.727 ± 0.045a 0.725 ± 0.051 6.2 7.0 0.801 0.668 0.002 ± 0.079
AD 1.625 ± 0.106b 1.614 ± 0.122 6.5 7.6 0.859 0.752 0.010 ± 0.161
RD 0.278 ± 0.051 0.280 ± 0.053 18.3 19.0 0.756 0.608  − 0.003 ± 0.093
Internal capsule (posterior) FA 0.699 ± 0.033c 0.689 ± 0.037 4.7 5.3 0.859 0.752 0.010 ± 0.046
ADC 0.706 ± 0.021d 0.702 ± 0.021 3.0 3.0 0.949 0.903 0.003 ± 0.018
AD 1.388 ± 0.053 1.371 ± 0.055 3.8 4.0 0.877 0.781 0.018 ± 0.065
RD 0.364 ± 0.030e 0.368 ± 0.034 8.2 9.2 0.912 0.839  − 0.004 ± 0.036
Corona radiata FA 0.502 ± 0.049f 0.491 ± 0.047 9.7 9.6 0.867 0.766 0.011 ± 0.063
ADC 0.700 ± 0.035g 0.708 ± 0.034 5.0 4.8 0.936 0.880  − 0.008 ± 0.030
AD 1.104 ± 0.050 1.105 ± 0.048 4.5 4.3 0.848 0.736  − 0.001 ± 0.071
RD 0.498 ± 0.048h 0.510 ± 0.050 9.7 9.8 0.917 0.846  − 0.012 ± 0.051
Centrum semiovale FA 0.542 ± 0.067 0.549 ± 0.060 12.3 11 0.894 0.809  − 0.007 ± 0.078
ADC 0.724 ± 0.030i 0.724 ± 0.029 4.2 4.0 0.976 0.953 0.000 ± 0.018
AD 1.210 ± 0.066 1.217 ± 0.049 5.5 4.0 0.764 0.618  − 0.008 ± 0.102
RD 0.481 ± 0.056 0.477 ± 0.052 11.7 11 0.938 0.882 0.004 ± 0.053
Uncinate fasciculus FA 0.566 ± 0.060j 0.566 ± 0.056 10.6 9.9 0.945 0.895  − 0.001 ± 0.054
ADC 0.784 ± 0.042 0.785 ± 0.041 5.3 5.3 0.954 0.912  − 0.001 ± 0.035
AD 1.351 ± 0.078 1.355 ± 0.063 5.8 4.6 0.882 0.789  − 0.004 ± 0.093
RD 0.500 ± 0.053 0.500 ± 0.059 10.5 11.8 0.963 0.929 0.000 ± 0.045
Forceps minor FA 0.505 ± 0.058k 0.505 ± 0.054 11.5 10.6 0.933 0.874 0.001 ± 0.057
ADC 0.771 ± 0.033 0.768 ± 0.034 4.3 4.5 0.940 0.887 0.003 ± 0.032
AD 1.246 ± 0.071 1.240 ± 0.063 5.7 5.0 0.893 0.807 0.006 ± 0.084
RD 0.533 ± 0.044 0.530 ± 0.053 8.3 10 0.946 0.897 0.003 ± 0.048
Thalamus FA 0.316 ± 0.026 0.311 ± 0.028 8.3 9.2 0.862 0.758 0.005 ± 0.037
ADC 0.758 ± 0.027 0.760 ± 0.027 3.5 3.5 0.960 0.924  − 0.001 ± 0.021
AD 1.004 ± 0.033 1.001 ± 0.035 3.2 3.5 0.914 0.842 0.003 ± 0.038
RD 0.635 ± 0.032 0.640 ± 0.029 5.0 4.5 0.917 0.847  − 0.004 ± 0.032
CC Genu FA 0.861 ± 0.040 0.864 ± 0.045 4.6 5.3 0.855 0.747  − 0.002 ± 0.061
ADC 0.757 ± 0.045 0.759 ± 0.047 6.0 6.2 0.829 0.708  − 0.001 ± 0.071
AD 1.822 ± 0.100 1.831 ± 0.101 5.5 5.5 0.886 0.796  − 0.010 ± 0.129
RD 0.225 ± 0.057 0.222 ± 0.064 25.4 28.7 0.857 0.750 0.003 ± 0.086
CC Splenium FA 0.853 ± 0.043 0.847 ± 0.041 5.0 4.8 0.877 0.781 0.006 ± 0.055
ADC 0.741 ± 0.057 0.748 ± 0.062 7.8 8.3 0.921 0.854  − 0.007 ± 0.064
AD 1.768 ± 0.131 1.766 ± 0.138 7.4 7.8 0.942 0.891 0.001 ± 0.127
RD 0.230 ± 0.060 0.238 ± 0.058 26.1 24.4 0.861 0.756  − 0.009 ± 0.082
  1. FA, fractional anisotropy; ADC, apparent diffusion coefficient; AD, axial diffusivity; RD, radial diffusivity; ICC, intraclass correlation coefficient; CV, coefficient of variation; CC, corpus callosum; diff, difference; SD, standard deviation
  2. Regions with significant differences between right (R) and left (L) cerebral hemispheres (p < 0.007):
  3. a,bCerebral peduncle (a) ADC: R 0.746 ± 0.062, L 0.707 ± 0.060 (b) AD: R 1.660 ± 0.138 L 1.592 ± 0.122;
  4. c,d,ePosterior limb of the Internal capsule: (c) FA: R 0.693 ± 0.037, L 0.707 ± 0.036 d) ADC: R 0.713 ± 0.025, L 0.698 ± 0.024
  5. (e) RD: R 0.373 ± 0.037, L 0.355 ± 0.031; (f,g,h) Corona radiata: (f) FA: R 0.693 ± 0.037, L 0.707 ± 0.036
  6. (g) ADC: R 0.713 ± 0.025, L 0.698 ± 0.024 (h) RD: R 0.373 ± 0.037, L 0.355 ± 0.031
  7. iCentrum Semiovale (i) ADC: R 0.731 ± 0.034, L 0.717 ± 0.032, jUncinate fasciculus (j) FA: R 0.575 ± 0.062, L 0.556 ± 0.064
  8. kForceps minor (k) FA: R 0.519 ± 0.070, L 0.491 ± 0.058