From: Micro-CT yields high image quality in human fetal post-mortem imaging despite maceration
Head images | Chest images | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Unadjusted | Adjusted | Unadjusted | Adjusted | |||||||||||
OR | 95% CI | p-value | R2 (%) | OR | 95% CI | p-value | OR | 95% CI | p-value | R2 | OR | 95% CI | p-value | |
Patient demographics | ||||||||||||||
Gestational Age (weeks) | − 0.014 | − 0.079, 0.052 | 0.678 | 0.1 | 0.076 | − 0.000, 0.152 | 0.050 | − 0.062 | − 0.113, − 0.010 | 0.020 | 2.1 | – | – | – |
Post Mortem Interval (days) | − 0.008 | − 0.039, 0.024 | 0.638 | 0.1 | – | – | – | − 0.005 | − 0.030, 0.020 | 0.685 | 0.1 | – | – | – |
Crown Rump Length (cm) | 0.004 | − 0.052, 0.060 | 0.891 | 0.0 | – | – | – | − 0.034 | − 0.078, 0.011 | 0.138 | 0.9 | – | – | – |
Crown Heel Length (cm) | 0.012 | − 0.027, 0.050 | 0.549 | 0.1 | – | – | – | − 0.018 | − 0.049, 0.013 | 0.254 | 0.5 | – | – | – |
Head Circumference (cm) | 0.021 | − 0.035, 0.077 | 0.464 | 0.2 | – | – | – | − 0.005 | − 0.050, 0.040 | 0.822 | 0.0 | – | – | – |
Post Mortem Weight (100 g) | − 0.004 | − 0.263, 0.255 | 0.976 | 0.0 | − 0.716 | − 1.074, − 0.357 | < 0.001 | − 0.029 | − 0.235, 0.178 | 0.785 | 0.0 | − 0.337 | − 0.550, − 0.114 | 0.003 |
Ab on Micro-CT (ref = no) | ||||||||||||||
Yes | 0.232 | − 0.139, 0.602 | 0.220 | 0.6 | – | – | – | 0.367 | 0.073, 0.660 | 0.015 | 2.6 | – | – | – |
Mode of death (ref = IUD) | ||||||||||||||
Miscarriage | 0.619 | 0.126, 1.110 | 0.014 | 0.469 | − 0.003, 0.940 | 0.051 | 0.219 | − 0.170, 0.608 | 0.269 | − 0.112 | − 0.480, 0.256 | 0.548 | ||
TOP | 1.170 | 0.623, 1.710 | < 0.001 | 6.9 | 0.826 | 0.253, 1.400 | 0.005 | 0.895 | 0.466, 1.320 | < 0.001 | 9.3 | 0.326 | − 0.122, 0.775 | 0.152 |
Maceration score (autopsy, ref = 0) | ||||||||||||||
1 | − 0.410 | − 0.956, 0.136 | 0.140 | − 0.523 | − 1.027, − 0.020 | 0.042 | − 0.450 | − 0.874, − 0.026 | 0.038 | − 0.616 | − 1.003, − 0.229 | 0.001 | ||
2 | − 1.110 | − 1.85, − 0.376 | 0.003 | − 0.931 | − 1.652, − 0.211 | 0.012 | − 0.655 | − 1.230, − 0.081 | 0.026 | − 0.815 | − 1.370, − 0.260 | 0.004 | ||
3 | − 0.690 | − 1.050, − 0.330 | < 0.001 | 6.6 | − 0.592 | − 1.048, − 0.136 | 0.011 | − 0.815 | − 1.090, − 0.535 | < 0.001 | 11.6 | − 0.830 | − 1.158, − 0.500 | < 0.001 |
Tissue Preparation | ||||||||||||||
Time to immersion (days) | − 0.006 | − 0.037, 0.024 | 0.694 | 0.1 | – | – | – | − 0.024 | − 0.046, − 0.001 | 0.039 | 2.3 | – | – | – |
Time iodinated (days) | 0.036 | − 0.040, 0.111 | 0.357 | 0.5 | – | – | – | 0.038 | − 0.018, 0.094 | 0.186 | 0.9 | – | – | – |
Imaging parameters | ||||||||||||||
Kilovoltage (per 100) | − 0.095 | − 1.210, 1.020 | 0.867 | 0.0 | – | – | – | 0.373 | − 0.516, 1.260 | 0.410 | 0.3 | – | – | – |
Current (100 µA) | 0.060 | − 0.295, 0.415 | 0.740 | 0.0 | – | – | – | − 0.170 | − 0.463, 0.123 | 0.254 | 0.5 | – | – | – |
Power (10 W) | 0.054 | − 0.273, 0.381 | 0.744 | 0.0 | – | – | – | − 0.099 | − 0.367, 0.169 | 0.469 | 0.2 | − 0.289 | − 0.548, − 0.029 | 0.029 |
Projections (100 s) | 0.095 | 0.065, 0.126 | < 0.001 | 12.8 | 0.102 | 0.070, 0.134 | < 0.001 | 0.060 | 0.031, 0.088 | < 0.001 | 6.0 | 0.044 | 0.015, 0.072 | 0.002 |
EPS (100 microns) | − 2.150 | − 3.310, − 0.982 | < 0.001 | 4.9 | – | – | – | − 1.650 | − 2.590, − 0.701 | < 0.001 | 4.4 | – | – | – |
Exposure time (100 ms) | 0.048 | − 0.075, 0.170 | 0.445 | 0.2 | – | – | – | 0.071 | − 0.027, 0.168 | 0.153 | 0.8 | 0.074 | − 0.022, 0.170 | 0.132 |
Frames per projection (ref = 1) | ||||||||||||||
2 | 0.332 | − 0.041, 0.706 | 0.081 | – | – | – | 0.600 | 0.291, 0.909 | < 0.001 | 0.639 | 0.341, 0.937 | < 0.001 | ||
4 | − 0.093 | − 1.210, 1.020 | 0.869 | 1.3 | – | – | – | − 0.453 | − 1.270, 0.360 | 0.273 | 7.3 | 0.178 | − 0.566, 0.921 | 0.638 |
Target (ref = Mo) | ||||||||||||||
W | 0.165 | − 0.383, 0.713 | 0.554 | 0.1 | – | – | – | 0.447 | 0.015, 0.879 | 0.043 | 1.6 | 0.358 | − 0.058, 0.774 | 0.091 |