Table 3 Comparison of the predictive performance of the five models in predicting Ki-67 expression
From: Radiomic analysis of Gd-EOB-DTPA-enhanced MRI predicts Ki-67 expression in hepatocellular carcinoma
Models | AUC (95% CI) | Sensitivity (%) | Specificity (%) | Accuracy (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|
AP radiomics model | ||||||
Training (n = 103) | 0.873 (79.3–93.0) | 92.5 (74/80) | 78.3 (18/23) | 89.3 (92/103) | 93.7 (74/79) | 75.0 (18/24) |
Validation (n = 48) | 0.813 (67.4–91.1) | 81.3 (26/32) | 81.3 (13/16) | 81.3 (39/48) | 89.7 (26/29) | 68.4 (13/19) |
Total (n = 151) | 0.837 (76.8 89.2) | 90.2 (101/112) | 69.2 (27/39) | 91.4 (138/151) | 89.4 (101/113) | 71.1 (27/38) |
HBP radiomics model | ||||||
Training (n = 103) | 0.813 (72.4–88.3) | 98.8 (79/80) | 47.8 (11/23) | 87.4 (90/103) | 86.8 (79/91) | 91.7 (11/12) |
Validation (n = 48) | 0.740 (59.3–85.6) | 84.4 (27/32) | 62.5 (10/16) | 89.6 (43/48) | 81.8 (27/33) | 66.7 (10/15) |
Total (n = 151) | 0.793 (72.0-85.5) | 87.5 (98/112) | 59.0 (23/39) | 80.1 (121/151) | 86.0 (98/114) | 62.2 (23/37) |
T2W radiomics model | ||||||
Training (n = 103) | 0.889 (81.2–94.4) | 72.5 (58/80) | 95.7 (22/23) | 77.7 (80/103) | 98.3 (58/59) | 50.0 (22/44) |
Validation (n = 48) | 0.698 (54.9–82.2) | 90.6 (29/32) | 43.8 (7/16) | 75.0 (36/48) | 76.3 (29/38) | 70.0 (7/10) |
Total (n = 151) | 0.823 (75.2, 88.0) | 67.9 (76/112) | 68.4 (27/39) | 68.2 (103/151) | 86.4 (76/88) | 42.9 (27/63) |
Combined AP and HBP radiomics model | ||||||
Training (n = 103) | 0.880 (0.802–0.936) | 86.2 (69/80) | 82.6 (19/23) | 70.9 (73/103) | 78.4 (69/88) | 26.7 (4/15) |
Validation (n = 48) | 0.799 (0.658–0.901) | 75.0 (24/32) | 75.0 (12/16) | 75.0 (36/48) | 85.7 (24/28) | 60.0 (12/20) |
Total (n = 151) | 0.852 (78.5, 90.4) | 83.9 (94/112) | 76.9 (30/39) | 82.1 (124/151) | 91.3 (94/103) | 62.5 (30/48) |
Combined modela | ||||||
Training (n = 103) | 0.922 (0.852–0.965) | 98.7 (79/80) | 78.3 (18/23) | 94.2 (97/103) | 94.0 (79/84) | 94.7 (18/19) |
Validation (n = 48) | 0.863 (73.3–94.5) | 90.6 (29/32) | 75.0 (12/16) | 85.4 (41/48) | 87.9 (29/33) | 80.0 (12/15) |
Total (n = 151) | 0.806 (73.4–86.6) | 83.0 (93/112) | 64.1 (25/39) | 78.1 (118/151) | 86.9 (93/107) | 56.8 (25/44) |