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Table 7 Factors that may affect induced chemotherapy response of MM from multivariable logistic regression

From: Correlations between apparent diffusion coefficient values of WB-DWI and clinical parameters in multiple myeloma

Characteristics Treatment response
CR sCR PR VGPR SD PD
Odds Ratio (95% confidence interval)
ADC value (× 10–3 mm2/s)
 0.3 < ADC ≤ 0.4 1.666 (3.439–8.069)   2.047 (1.063–1.593) 0.496 (0.631–2.789)* 0.136 (0.280–1.068)* 1.268 (0.445–1.116)*
 0.4 < ADC ≤ 0.5 1.917 (3.912–9.396)   0.110 (0.016–0.740)* 0.755 (0.755–1.227)* 1.811 (1.961–6.727) 0.496 (0.208–2.398)
 0.5 < ADC ≤ 0.6 3.817 (9.868–14.778)   0.692 (0.115–4.160)* 0.349 (0.129–0.974)* 4.432 (0.427–1.163) 1.219 (.0.598–1.530)
 0.7 < ADC ≤ 0.8 5.752 (2.178–15.198)   1.658 (0.376–7.304)* 0.798 (0.476–1.232)* 7.816 (0.920–1.335) 0.553 (0.181–0.910)*
 0.8 < ADC ≤ 0.9 1.121 (4.730–2.658)*   5.999 (1.761–20.428) 0.898 (1.497–10.687) 1.632 (3.132–8.499) 0.990 (0.202–1.392)*
 0.9 < ADC ≤ 1.0 0.651 (0.914–1.716)*   1.231 (0.339–4.466) 1.452 (3.523–5.986)* 0.608 (0.147–1.705)* 0.802 (0.779–1.252)*
 1.0 < ADC ≤ 1.1 3.906 (0.879–1.860)   3.171 (0.339–4.466) 1.501 (2.009–3.452)* 3.917 (3.890–7.998) 1.054 (0.371–1.529)*
 1.1 < ADC ≤ 1.2 2.925 (1.334–6.776)   2.496 (7.886–9.009) 1.453 (1.650–2.221)* 1.595 (3.435–4.667) 0.510 (3.445–8.956)*
 1.2 < ADC ≤ 1.3 1.334 (6.004–9.657)* Reference 0.399 (0.111–1.433) 1.562 (1.312–9.673)* 0.110 (0.005–1.127)* 0.849 (0.445–1.956)*
 1.3 < ADC ≤ 1.4 1.679 (0.679–1.679)   1.957 (0.598–6.410) 1.024 (0.034–1.024) 4.008 (0.008–0.995) 1.389 (0.672–1.334)
 1.4 < ADC ≤ 1.5 1.355 (0.066–1.445)   1.769 (0.998–1.884) 1.886 (0.554–0.981) 0.776 (0.549–1.886)* 0.679 (0.630–1.086)
Gene variation
 p32 deletion 0.182 (2.397–35.169)   0.678 (2.586–4.089)* 3.725 (2.245–4.682) 1.733 (1.198–4.990) 0.645 (0.009–1.879)*
 P53 deletion 0.053 (1.609–10.206)*   0.942 (2.847–16.927) 3.725 (0.242–1.535) 0.359 (0.867–1.007)* 1.828 (1.905–3.445)*
 RB1 deletion 1.600 (0.856–2.991)   2.104 (1.072–4.129) 1.600 (0.768–3.331) 0.290 (0.065–2.005) 1.492 (0.067–1.992)*
 q21 amplification 0.050 (1.089–3.860)*   1.319 (0.639–2.723)** 4.239 (2.047–8.779)* 1.632 (0.494–5.392) 0.985 (0.181–5.355)*
 IGH rearrangement 0.640 (0.278–1.475)   0.824 (0.332–2.045) 0.205 (0.074–0.565) 0.993 (0.072–2.067)* 0.346 (0.064–1.729)*
  1. ADC apparent diffusion coefficient, CR complete response, PD progressive disease, PR partial response, sCR strict complete response, SD sable disease, VGPR vary good partial response
  2. p value for the model is less than 0.001. A single asterisk (*) implies statistically significant