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Table 3 Within-subjects ADC value change after chemotherapy

From: Correlations between apparent diffusion coefficient values of WB-DWI and clinical parameters in multiple myeloma

Parameters Baseline visit After 4-course chemotherapy p value
ADC value (× 10–3 mm2/s) 0.8556 (0.7130–1.361) 1.0076 (0.8817–1.3336) < 0.001a
Therapeutic response
 CR 0.8561 (0.7890–1.3884) 1.1330 (0.9887–1.3883) < 0.001a
 sCR 0.6772 (0.5985–0.9066) 0.9756 ± 0.2724 < 0.001a
 PR 0.8673 (0.7912–1.3301) 1.0961 ± 0.2724 < 0.001a
 VGPR 0.9555 ± 0.3326 1.0667 ± 0.2537 0.004a
 SD 1.3883 (0.8290–1.3891) 1.2588 ± 0.2467 0.151
 PD 0.8504 ± 0.0602 1.0206 ± 0.8934 0.089
Plasma cell infiltration (%) 44.35 ± 23.11 5.01 ± 7.62 < 0.001a
Albumin (g/L) 34.36 ± 7.31 37.44 ± 7.03 < 0.001a
LDH (U/L) 222.41 ± 85.29 227.94 ± 48.14 0.570
β2 microglobulin (μg/mL) 8.75 ± 7.15 4.27 ± 3.00 < 0.001a
  1. ADC apparent diffusion coefficient, CR complete response, LDH  lactic dehydrogenase, PD progressive disease, PR partial response, sCR strict complete response, SD sable disease, VGPR vary good partial response
  2. aSignificant difference