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Table 1 Patient characteristics, EOB MRI findings, CE behavior, and qualitative MRI features in a histopathological subgroup analysis of FNH and HCA

From: HBP-enhancing hepatocellular adenomas and how to discriminate them from FNH in Gd-EOB MRI

  Reader 1 Reader 2 p value
Overall
n = 68
FNH
n = 28
HCA
n = 40
Overall
n = 68
FNH
n = 28
HCA
n = 40
Patient characteristics
Sex (female) 87% (59) 100% (28) 77.5% (31) 0.007
Age (years) 40 ± 12 38 ± 10 43 ± 13  > 0.05*
Lesion diameter (mm) 59 ± 36 64 ± 34 56 ± 39  > 0.05*
Steatosis 41% (28) 14.5% (4) 35% (14) 0.227
HCA subtypes
IHCA 54.5% (37) 92.5% (37)
HHCA 1.5% (1) 2.5% (1)
bHCA 1.5% (1) 2.5% (1)
uHCA 1.5% (1) 2.5% (1)
Accuracy (%) 94% (64) 89% (25) 97.5% (39) 94% (64) 100% (28) 90% (36)  < 0.001
(0.835)
Intralesional Gd-EOB uptake scores
Score 4: > 75% 40% (27) 82% (23) 12.5% (5) 47% (32) 96.5% (27) 12.5% (5)  
Score 3: 50–75% 19% (13) 7% (2) 27.5% (11) 20.5% (14) 0 35% (14)  
Score 2: 25–50% 41% (28) 11% (3) 60%  (24) 32.5% (22) 3.5% (1) 52.5% (21)  
Score 1: 5–25% 0 0 0 0 0 0  < 0.001*
Score 0: < 5%
Interreader correlation
0 0 0 0 0 0  < 0.001
(0.872)
Intralesional Gd-EOB uptake
Entirely enhancing lesion 40% (27) 82% (23) 12.5% (5) 47% (32) 96.5% (27) 12.5% (5)  
Significantly enhancinglesion 60% (41) 8% (5) 87.5% (35) 53% (36) 3.5% (1) 87.5% (35)  < 0.001*
Gd-EOB uptake pattern
Homogeneous 79.5% (54) 93% (26) 30% (12) 69% (47) 86% (24) 57.5% (23)  < 0.001*
Heterogeneous / patchy
Interreader correlation
20.5% (14) 7% (2) 70% (28) 31% (21) 14% (4) 42.5% (17)  < 0.001
(0.604)
CE behavior** n = 65* n = 25* n = 40* n = 65* n = 25* n = 40*  
Qualitative
Art. hyperenhancement 89% (58) 88% (22) 87.5% (35) 89% (58) 96% (24) 85% (34) 0.952*
Portal venous wash-out 9% (6) 4% (1) 12.5% (5) 14% (9) 8% (2) 17.5% (7) 0.249*
Quantitative
Arterial phase 339.2 ± 223.2 290.2 ± 197.5 358..0 ± 241.0 0.279
Poral venous phase 118.9 ± 49.5 132.9 ± 43.4 110.2 ± 51.4 0.048
Venous phase 108.7 ± 42.6 122.0 ± 32.6 100.3 ± 46.2 0.107
Hepatobiliary phase 79.7 ± 45.8 110.3 ± 39.2 59.2 ± 38.0  < 0.001
Qualitive MRI features
Lobulated appearance 55% (36) 89% (25) 27.5% (11) 54.5% (37) 82% (23) 35% (14)  < 0.001*
Pseudocapsule 17.5% (12) 11% (3) 22.5% (9) 28% (19) 32% (9) 25% (10) 0.210*
Central scar 35.5% (24) 46.5% (13) 27.5% (11) 56% (38) 89.5% (25) 32.5% (13) 0.046*
Intralesional fat 9% (6) 8% (2) 10% (4) 10.5% (7) 8% (2) 12.5% (5) 0.768*
Atoll sign 10.5% (7) 4% (1) 15% (6) 19% (13) 3.3% (1) 30% (12) 0.164*
  1. Bold values indicate p < 0.05
  2. * p-values—referring to the results of Reader #1 (highly experienced radiologist)
  3. **CE behavior: In two patients / three lesions, quality of CE dynamics was insufficient (max. n = 65)