Table 1 Patient characteristics, EOB MRI findings, CE behavior, and qualitative MRI features in a histopathological subgroup analysis of FNH and HCA

Patient characteristics

Sex (female)

87% (59)

100% (28)

77.5% (31)

–

–

–

0.007

Age (years)

40 ± 12

38 ± 10

43 ± 13

–

–

–

 > 0.05*

Lesion diameter (mm)

59 ± 36

64 ± 34

56 ± 39

–

–

–

 > 0.05*

Steatosis

41% (28)

14.5% (4)

35% (14)

–

–

–

0.227

HCA subtypes

IHCA

54.5% (37)

–

92.5% (37)

–

–

–

–

HHCA

1.5% (1)

–

2.5% (1)

–

–

–

–

bHCA

1.5% (1)

–

2.5% (1)

–

–

–

–

uHCA

1.5% (1)

–

2.5% (1)

–

–

–

–

Accuracy (%)

94% (64)

89% (25)

97.5% (39)

94% (64)

100% (28)

90% (36)

 < 0.001

(0.835)

Intralesional Gd-EOB uptake scores

Score 4: > 75%

40% (27)

82% (23)

12.5% (5)

47% (32)

96.5% (27)

12.5% (5)

Score 3: 50–75%

19% (13)

7% (2)

27.5% (11)

20.5% (14)

0

35% (14)

Score 2: 25–50%

41% (28)

11% (3)

60%  (24)

32.5% (22)

3.5% (1)

52.5% (21)

Score 1: 5–25%

0

0

0

0

0

0

 < 0.001*

Score 0: < 5%

Interreader correlation

0

0

0

0

0

0

 < 0.001

(0.872)

Intralesional Gd-EOB uptake

Entirely enhancing lesion

40% (27)

82% (23)

12.5% (5)

47% (32)

96.5% (27)

12.5% (5)

Significantly enhancinglesion

60% (41)

8% (5)

87.5% (35)

53% (36)

3.5% (1)

87.5% (35)

 < 0.001*

Gd-EOB uptake pattern

Homogeneous

79.5% (54)

93% (26)

30% (12)

69% (47)

86% (24)

57.5% (23)

 < 0.001*

Heterogeneous / patchy

Interreader correlation

20.5% (14)

7% (2)

70% (28)

31% (21)

14% (4)

42.5% (17)

 < 0.001

(0.604)

CE behavior**

n = 65*

n = 25*

n = 40*

n = 65*

n = 25*

n = 40*

Qualitative

Art. hyperenhancement

89% (58)

88% (22)

87.5% (35)

89% (58)

96% (24)

85% (34)

0.952*

Portal venous wash-out

9% (6)

4% (1)

12.5% (5)

14% (9)

8% (2)

17.5% (7)

0.249*

Quantitative

Arterial phase

339.2 ± 223.2

290.2 ± 197.5

358..0 ± 241.0

–

–

–

0.279

Poral venous phase

118.9 ± 49.5

132.9 ± 43.4

110.2 ± 51.4

–

–

–

0.048

Venous phase

108.7 ± 42.6

122.0 ± 32.6

100.3 ± 46.2

–

–

–

0.107

Hepatobiliary phase

79.7 ± 45.8

110.3 ± 39.2

59.2 ± 38.0

–

–

–

 < 0.001

Qualitive MRI features

Lobulated appearance

55% (36)

89% (25)

27.5% (11)

54.5% (37)

82% (23)

35% (14)

 < 0.001*

Pseudocapsule

17.5% (12)

11% (3)

22.5% (9)

28% (19)

32% (9)

25% (10)

0.210*

Central scar

35.5% (24)

46.5% (13)

27.5% (11)

56% (38)

89.5% (25)

32.5% (13)

0.046*

Intralesional fat

9% (6)

8% (2)

10% (4)

10.5% (7)

8% (2)

12.5% (5)

0.768*

Atoll sign

10.5% (7)

4% (1)

15% (6)

19% (13)

3.3% (1)

30% (12)

0.164*