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Table 2 Brain MRI findings in patients with AOE

From: Methadone-induced encephalopathy: a case series and literature review

Number

Age/ Sex

Bilateral cerebral white matter T2 and FLAIR hyperintensity

Bilateral cerebellar white and gray matter T2 and FLAIR hyperintensity

Bilateral parieto-occipital T2 and FLAIR hyperintensity (PRES features)

Internal capsule involvement

Other structures

Infarction

Hemorrhage

1

13 yr, F

Yes

Yes

Yes

–

–

No

No

2

16 yr, F

Yes

–

–

–

–

No

No

3

23mo, M

Yes

–

–

–

–

No

No

4

30 yr, M

–

Yes

Yes

With restriction in DWI and low signal in ADC sequences

–

–

No

No

5

31 yr, M

Yes

–

–

Yes

Splenium of corpus callosum

No

No

6

32 yr, F

–

–

Yes

With restriction in DWI and low signal in ADC sequences

–

–

No

No

7

33 yr, M

Yes

–

–

Yes with restriction in DWI and ADC sequences

–

No

No

8

5 yr, M

–

Yes

Yes

With restriction in DWI and low signal in ADC sequences

–

Globus pallidus and caudate nuclei

No

No