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Table 1 Characteristics of patients in training set and validation set

From: Cervical spine osteoradionecrosis or bone metastasis after radiotherapy for nasopharyngeal carcinoma? The MRI-based radiomics for characterization

Characteristics

Training set (n = 46)

P value

Validation set (n = 25)

P value

 

ORN

Metastasis

 

ORN

Metastasis

 

Number of patients (n)

25 (54.3%)

21 (45.7%)

 

14 (56.0%)

11 (44.0%)

 

Gender

 Male

19 (76.0%)

15 (71.4%)

0.725

11 (78.6%)

8 (72.7%)

0.739

 Female

6 (24.4%)

6 (28.6%)

 

3 (21.4%)

3 (27.3%)

 

 Age (years)

50.0 ± 10.8

49.1 ± 11.7

0.790

51.8 ± 10.7

48.9 ± 10.5

0.735

Over stagea

 I

2 (8.0%)

1 (4.8%)

0.886

1 (7.1%)

1 (9.1%)

0.901

 II

10 (40.0%)

7 (33.3%)

 

4 (28.6%)

2 (18.2%)

 

 III

8 (32.0%)

6 (28.6%)

 

6 (42.9%)

4 (36.4%)

 

 IVA

3 (12.0%)

4 (19.0%)

 

2 (14.3%)

2 (18.2%)

 

 IVB

2 (8.0%)

3 (14.3%)

 

1 (7.1%)

2 (18.2%)

 

 Involvement multiple lesions

19 (76.0%)

16 (76.2%)

 

10 (71.4%)

9 (81.8%)

 

 Overall RT dose (Gy)

69.5 ± 12.3

67.4 ± 17.8

0.617

73.2 ± 9.6

73.0 ± 10.9

0.637

 Concurrent chemotherapy

22 (88.0%)

20 (95.2%)

0.373

13 (92.9%)

10 (90.9%)

0.476

 Interval time from first RT to lesion detection (mouth)

36.1 ± 26.3

41.3 ± 25.6

0.498

31.3 ± 22.5

32.1 ± 16.2

0.060

 Cervical lymphadenopathyb

2 (8.0%)

7 (33.3%)

0.033

0 (0.0%)

4 (36.4%)

0.006

 Radiation-induced brain necrosis

2 (8.0%)

1 (4.8%)

0.654

1 (7.1%)

0 (0%)

0.275

  1. a, According to the 7th UICC/AJCC staging system; b, short axis larger than 1 cm on axial images; ORN Osteoradionecrosis;
  2. RT Radiotherapy