Differential diagnosis between hepatic alveolar echinococcosis and intrahepatic cholangiocarcinoma with conventional ultrasound and contrast-enhanced ultrasound

Table 4 Diagnostic Performance of BUS and/or CEUS for Differentiating between HAE and ICC

	Sensitivity^a	95% CI^a	Specificity^a	95% CI^a	AUC	95% CI	LR+	LR-
BUS + CEUS score
Training set	82.5	67.2–92.7	86.4	72.6–94.8	0.913	0.832–0.964	6.05	0.20
Testing set	80.0	56.3–94.3	81.3	54.4–96.0	0.905	0.760–0.977	4.27	0.25
≤ 5.0 cm	72.7	49.8–89.3	91.7	73.0–99.0	0.912	0.791–0.975	8.73	0.30
BUS score
Training set	67.5	50.9–81.4	100.0	92.0–100.0	0.886	0.798–0.945	NA	0.33
Testing set	60.0	36.1–80.9	100.0	79.4–100.0	0.925	0.786–0.986	NA	0.40
≤ 5.0 cm	45.5	24.4–67.8	100.0	85.8–100.0	0.875	0.744–0.954	NA	0.55
CEUS score
Training set	82.5	67.2–92.7	65.9	50.1–79.5	0.777	0.673–0.861	2.42	0.27
Testing set	65.0	40.8–84.6	68.9	41.3–89.0	0.717	0.543–0.854	2.08	0.51
≤ 5.0 cm	72.7	49.8–89.3	75.0	53.3–90.2	0.773	0.625–0.883	2.91	0.36

^a Numbers are percentages
HAE Hepatic alveolar echinococcosis; ICC Intrahepatic cholangiocarcinoma; CEUS Contrast enhanced ultrasound; AUC Area under the curve; PPV Positive predictive value; NPV Negative predictive value

ISSN: 1471-2342