Fig. 1

Upper row: A 35-year-old female with diffuse astrocytoma with mutant IDH1 in the right frontal lobe. A transverse T2-weighted image shows a homogeneous hyperintensity area in the right frontal lobe (a). A contrast enhanced transverse T1-weighted image shows no enhancement in the tumor (b). ADC signal was elevated (c). The APT-weighted image shows a mild increase signal in the tumor compared with normal brain tissue (d). The CBF map showed low CBF in the tumor (e). Middle row: A 66-year-old female patient with diffuse astrocytoma with mutant IDH1 showed a heterogeneously hyperintense area in the right temporal lobe in transverse T2-weighted image (f). A contrast enhanced transverse T1-weighted image shows a miner enhancement in the tumor (g). ADC signal was slightly elevated (h). The APT-weighted image shows mild increase signal in the tumor (i). The CBF map showed high CBF in the tumor (j). Lower row: A 43-year-old female with a glioblastoma with wide-type IDH1 in the left thalami and temporal lobe. A transverse T2-weighted image shows a heterogeneously hyperintense area in the left temporal lobe (k). No obvious local enhancement was observed in postcontrast T1-weighted image (l). ADC signal was not uniformly reduced (m). APT-weighted image shows high signal in the tumor compared with normal brain tissue (n). The CBF map showed no high signal in the tumor (o)