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Table 2 Features suggestive of adverse and benign changes in both nodes and bones

From: Localising occult prostate cancer metastasis with advanced imaging techniques (LOCATE trial): a prospective cohort, observational diagnostic accuracy trial investigating whole–body magnetic resonance imaging in radio-recurrent prostate cancer

 Benign featuresAdverse features
NodeLymph node <5 mm in short axis diameter (SAD) with no concerning features on DWI, T2 weighted or contrast enhanced imaging and definite benign features e.g.
(i) Fatty hilum,
(ii) Oval nodal morphology with clearly defined and
(iii) Regular nodal border and contours.
Concerning features could be described as
(i) Size above normal limit e.g. > 10 mm for most,
(ii) Loss of fatty hilum,
(iii) Irregular border,
(iv) Asymmetric high DWI signal intensity,
(v) Low T2 signal
BoneNormal appearing bone with uniform moderate-high signal on T1 weighted imaging and low-moderate signal on T2 weighted imaging.
Focal lesions demonstrating clearly incidental/benign multiparametric signal characteristics and/or location
(i) Increase in DWI high b-value signal vs. background noise.
(ii) Low signal intensity on T1 and (iii) Intermediate to high signal intensity on T2
(iv) Lesional contrast enhancement
  1. DWI Diffusion weighted imaging