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Table 5 Diagnostic Performance of US Characteristics for the Prediction of Malignancy in Thyroid Nodules with Echogenic foci Types with TIRADS Combination (Low suspicion)

From: Echogenic foci in thyroid nodules: diagnostic performance with combination of TIRADS and echogenic foci

Echogenic foci

TIRADS

Total

Benign

Malignant

Diagnostic Performance

Sensitivity

Specificity

Accuracy

PPV

NPV

Type 1

+ Web-based TIRADS (<  8)

59

40

19

7.5

70.6

29.5

32.2

29.0

+ K-TIRADSa

51

35

16

6.3

74.3

30.0

31.4

29.8

+ ATAa

10

8

2

0.9

88.4

22.3

20.0

22.4

+ Russ et al. (< 4B)

18

13

5

2.0

90.4

32.8

27.8

33.1

Type 2

+ Web-based TIRADS (<  8)

17

9

8

5.2

83.3

27.1

47.1

23.7

+ K-TIRADSa

14

6

8

5.2

88.9

25.6

57.1

24.9

+ ATAa

3

2

1

0.7

93.1

16.2

33.3

15.9

+ Russ et al. (<4B)

7

4

3

2.0

92.6

25.6

42.9

25.0

Type 3

+ Web-based TIRADS (< 8)

72

39

33

13.0

71.3

33.3

45.8

30.5

+ K-TIRADSa

57

35

22

8.7

74.3

31.5

38.6

30.3

+ ATAa

19

17

2

0.9

75.4

19.1

10.5

19.8

+ Russ et al. (<4B)

45

28

17

6.7

79.4

32.1

37.8

31.3

Type 4

+ Web-based TIRADS (<  8)

25

15

10

3.9

89.0

33.6

40.0

33.2

+ K-TIRADSa

23

15

8

3.1

89.0

33.1

34.8

33.0

+ ATAa

6

5

1

0.5

92.8

23.0

16.7

23.2

+ Russ et al. (<4B)

21

14

7

2.8

89.7

33.1

33.3

33.1

Type 5

+ Web-based TIRADS (< 8)

15

12

3

1.2

91.2

32.6

20.0

33.1

+ K-TIRADSa

16

13

3

1.2

90.4

32.3

18.8

32.9

+ ATAa

6

5

1

0.5

92.8

23.0

16.7

23.2

+ Russ et al. (<4B)

15

12

3

1.2

91.2

32.6

20.0

33.1

Type 6

+ Web-based TIRADS (<  8)

20

9

11

4.3

93.4

35.4

55.0

34.3

+ K-TIRADSa

17

10

7

2.8

92.6

34.1

41.2

33.8

+ ATAa

6

4

2

0.9

94.2

23.8

33.3

23.6

+ Russ et al. (< 4B)

13

8

5

2.0

94.1

34.1

38.5

34.0

  1. TIRADS thyroid image reporting and data system, ATA american thyroid association, PPV positive predictive value, NPV negative predictive value
  2. aOther than High suspicion category
  3. Type 1 = Punctate echogenic foci (≤ 1 mm) with or without posterior shadowing
  4. Type 2 = Punctate echogenic foci with comet-tail artifact
  5. Type 3 = Large echogenic foci (> 1 mm) without shadowing
  6. Type 4 = Macrocalcification (defined as large echogenic foci (> 1 mm) with shadowing
  7. Type 5 = Peripheral curvilinear or eggshell echogenic foci with or without shadowing
  8. Type 6 = Nodules with more than one type of echogenic foci