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Table 3 Diagnostic Performance of US Characteristics for the Prediction of Malignancy in Thyroid Nodules with Echogenic Foci alone and TIRADS alone

From: Echogenic foci in thyroid nodules: diagnostic performance with combination of TIRADS and echogenic foci

 

Total

Benign

Malignant

Diagnostic Performance

Sensitivity

Specificity

Accuracy

PPV

NPV

Echogenic Foci

Type 1

207

54

153

60.2

60.3

60.3

73.9

44.8

Type 2

54

12

42

27.5

77.8

40.6

77.8

27.5

Type 3

94

41

53

20.9

69.9

37.9

56.4

32.1

Type 4

27

16

11

4.3

88.2

33.6

40.7

33.1

Type 5

21

14

7

2.8

89.7

33.1

33.3

33.1

Type 6

41

11

30

11.8

91.9

39.7

73.2

35.8

TIRADS

Web-based TIRADS(≥ 8)

199

21

178

70.1

84.6

75.1

89.4

60.2

K-TIRADS High Suspicion

226

28

198

78.0

79.4

78.5

87.6

65.9

ATA guidelines High Suspicion

235

30

205

96.2

56.5

86.5

87.2

83.0

Russ et al. (≥ 4B)

278

61

217

85.4

55.1

74.9

78.1

67.0

  1. TIRADS thyroid image reporting and data system, ATA american thyroid association, PPV positive predictive value, NPV negative predictive value
  2. Type 1 = Punctate echogenic foci (≤ 1 mm) with or without posterior shadowing
  3. Type 2 = Punctate echogenic foci with comet-tail artifact
  4. Type 3 = Large echogenic foci (> 1 mm) without shadowing
  5. Type 4 = Macrocalcification (defined as large echogenic foci (> 1 mm) with shadowing)
  6. Type 5 = Peripheral curvilinear or eggshell echogenic foci with or without shadowing
  7. Type 6 = Nodules with more than one type of echogenic foci