Table 8 Previous serial ROI studies of DTI in ALS
Study | Number of subjects | Mean Age (sd) at first study | Mean ALS FRS-R (sd) at first study | Mean ALS FRS R (sd) at second study | Field Strength | Duration of study | Significant ROI changes |
|---|---|---|---|---|---|---|---|
Kwan et al. [8] | 9 | 57.2 (12.6) | 40.2 (6.3) | 34.1 (9.8) | 3 T | Mean of 1.26 years | No change in CR, pons, CST |
Steinbach [49] | 16 | 62.1 (11.7) | 41.0 (3.6) | 38.2 (4.6) | 3 T | 3 months | No change in CST, Increased connectivity in Hpc |
Cardenas–Blanco [54] | 34 | 57.3 (9.9) | 40.2 (4.4) | 37.9 (5.3) | 3 T | Mean of 6 months | No change over time in ALS group |
Zhang [36] | 17 | 57.3 (10) | 35.1 (7.1) | 29.2 (9.3) | 4 T | Mean of 8.1 months | Significant decline in FA in R CST |
Keil [52] | 15 | 61.5 (10.9) | 36.3 (9.0) | na | 1.5 T | 6 months | Decline in FA in CST |
Nickerson [14] | 2 | 48 | na | na | 3 T | 12 months | Decrease in FA in CST |
Mitsumoto [17] | 30 | 52.6 (10.9) | 36.4 (7.8) | na | 1.5 T | 9.2 months | No change in CST with FA |
Menke [48] | 27 | 61 (11) | 35 (6) | na | 3 T | Mean 16 months | No change over time |
Bede et al. [47] | 32 | 59.9 (9.9) | 39.31 (6.4) | 33.88 (7.8) | 3 T | Mean of 273 days | No change in DTI over time |