Fig. 6

Neuroanatomical differentiation of both ex vivo and in vivo micro-CT scan are enhanced by NLM denoising. The original (Aa) and denoised (Ba) ex vivo scans illustrate sharper periventricular edges seen in (Ba) while gross neuroanatomical details are preserved in both. The difference in image noises is more obvious when comparing the respective magnified views, (Ab) and (Bb). Similar but more prominent edge enhancements is shown by the comparison of (Ca) and (Da), original and denoised in vivo micro-CT scans, respectively. The markedly improved signal-to-noise ratio is easily appreciated in the magnified denoised (Db) from the original (Cb) views. The respective grayscale line profile of each scan revealed reductions in intensity variability in denoised group, (Bc) and (Dc), in comparison to the originals, (Ac) and (Cc)