Fig. 1

Sample images and segmentations results. Representative baseline cervical spinal cord T2-weighted axial images (taken at C3) from three patients with RRMS on interferon β-1a treatment. The corresponding region-of-interest (red oval) resulting from the semiautomated cord contouring tool is also shown. The normalized spinal cord area (SCA) for each patient, determined from C1-C5, is listed below the images. a A patient with a disease duration (DD) of 19.4 years, Expanded Disability Status Scale (EDSS) score of 2.0, and timed 25-foot walk (T25FW) of 4.0 s. b A patient with DD 4.4 years, EDSS 2.5, and T25FW 5.7 s. c A patient with DD 24.4 years, EDSS 1.5, T25FW 4.0 s, in whom successful spinal cord contouring was performed despite the presence of a T2 hyperintense spinal cord lesion (indicated with arrow)