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Table 1 Timeline

From: Counter-clockwise vortical blood flow in the main pulmonary artery in a patient with patent ductus arteriosus with pulmonary arterial hypertension: a cardiac magnetic resonance imaging case report

1993:

Preterm birth (35th week of pregnancy); bronchopulmonary dysplasia; severe obstructive pulmonary disease

1994:

Echocardiography: enlarged RV and RA; normal LV and LA; small PDA with left-to-right shunt

2006:

Aortic angiography: PDA diameter, 3.5 mm

Right heart catheterization and PDA trial occlusion: mPAP, 70 mmHg; RV pressures did not significantly decrease after trial occlusion

Echocardiography: RV/LV/PV diameter, 24/55/34 mm; maximal pressure gradient across PDA, 16 mmHg

2006 – 2014:

Bosentan therapy and close meshed therapy monitoring

2008:

Echocardiography: RV/LV/PV diameter, 28/54/35 mm; maximal pressure gradient across PDA, 16 mmHg

Right heart catheterization and PDA trial occlusion: PAP, 94/53/70 mmHg; RAP, 4 mmHg. RV pressures did not significantly decrease after trial occlusion

2013:

Echocardiography: RV/LV/PV diameter, 24/59/39 mm

2014:

Right heart catheterization: see case presentation. Clinical classification: PAH associated with congenital heart disease (PDA) according to positive treatment effect of Bosentan

Cardiac MR: see case presentation

since 2014:

Macitentan therapy

  1. PDA, patent ductus arteriosus, RV right ventricle, LV left ventricle, PV pulmonary valve, RVP systolic/diastolic/mean, right ventricular pressure, PAP systolic/diastolic/mean, pulmonary arterial pressure, RAP right atrial pressure, PAH pulmonary arterial hypertension