Differences in sex distribution, anatomic location and MR imaging appearance of pediatric compared to adult chordomas

Table 1 Study sample demographics

	Pediatric subjects	Adult subjects	P-value
Age at diagnosis (mean, range)	10.0 (1–20)	55.8 (21–89)	<2.2 × 10⁻¹⁶
Sex (N, (% Male))	23 (41.1)	95 (57.9)	0.04
Race/ethnicity (N, (%))^a
Asian	0 (0)	4 (2.7)	0.61
Black/African-American	2 (5.3)	1 (0.7)	0.01
Hispanic	2 (5.3)	5 (3.3)	0.83
Caucasian	34 (89.5)	140 (93.3)	0.53
Type (N, (%))^b
Chondroid	10 (17.9)	34 (20.7)	0.79
Conventional	46 (82.1)	126 (76.8)	0.52
Dedifferentiated	0 (0.0)	4 (2.4)	0.55
Location (N, (%))^c
Clivus/skull base	35 (62.5)	47 (28.7)	5.0 × 10⁻⁶
Clivus/skull base and cervical	4 (7.1)	1 (0.6)	1.8 × 10⁻²
Cervical	10 (17.9)	25 (15.2)	0.74
Thoracic	3 (5.4)	13 (7.9)	0.77
Lumbar	1 (1.8)	18 (11.0)	0.07
Sacrococcygeal	1 (1.8)	59 (36.0)	2.4 × 10⁻⁶

^a14 adult and 18 pediatric subjects declined to report race/ethnicity
^b60 adult and 32 pediatric subjects’ pathology reports listed chordoma as final diagnosis. These were categorized as conventional chordomas based on discussion with the pathologist
^c1 adult and 2 pediatric subjects did not have imaging confirmation of the anatomic location of their lesions

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