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Table 1 Accumulation comparison of 18F-FAC, 18F-FPA, 18F-FBA and 18F-FDG (3.7 MBq in saline) in model mice (n = 3)

From: Comparison of three 18F-labeled carboxylic acids with 18F-FDG of the differentiation tumor from inflammation in model mice

 

18F-FDG

18F-FAC

18F-FPA

18F-FBA

Blooda

0.72 ± 0.18

3.36 ± 1.66

4.35 ± 1.09

0.05 ± 0.01

Musclea

1.06 ± 0.47

3.73 ± 0.53

3.87 ± 0.42

0.22 ± 0.02

Tumora

6.67 ± 1.13

6.12 ± 1.76

6.51 ± 1.28

0.63 ± 0.10

Inflammationa

4.11 ± 1.96

5.10 ± 0.33

4.62 ± 0.33

0.31 ± 0.04

Tumor-to-Bloodb

1.68 ± 0.26

1.82 ± 0.45

1.50 ± 0.36

12.60 ± 2.12

Inflammation-to-Blood

1.03 ± 0.14

1.52 ± 0.21

1.06 ± 0.26

6.20 ± 1.06

Tumor-to-Muscle

6.30 ± 0.69

1.70 ± 0.16

1.80 ± 0.19

2.76 ± 0.25

Inflammation-to-Muscle

3.87 ± 0.61

1.42 ± 0.13

1.38 ± 0.13

1.40 ± 0.13

Tumor-to-Inflammation

1.63 ± 0.28

1.20 ± 0.38

1.41 ± 0.33

1.98 ± 0.15*

SI (Blood)c

1.76 ± 0.23

1.59 ± 0.12

8.00 ± 1.37*

2.23 ± 0.34

SI (Muscle)d

1.84 ± 0.17

1.74 ± 0.16

3.52 ± 0.13*

3.72 ± 0.06*

  1. aValues were presented as % ID/g (mean ± SD)
  2. bDefined as (Tumor uptake)/(Blood uptake)
  3. cDefined as (Tumor uptake − Blood uptake)/ (Inflammation uptake − Blood uptake), that is, Tu/Inf ratio corrected for blood background activity
  4. dTu/Inf ratio corrected for Muscle background activity
  5. *p < 0.05, vs. the ratios for 18F-FDG