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Table 3 Number of focal lesions and ADC, CBF, CBV and MTT values in C3 and C4

From: A semi-automated measuring system of brain diffusion and perfusion magnetic resonance imaging abnormalities in patients with multiple sclerosis based on the integration of coregistration and tissue segmentation procedures

 

C3 lesions

C4 lesions

 

First reader

Second reader

p value

Kappa value

First reader

Second reader

p value

Kappa value

Lesion number (sum, median, IQR, mean ± SD, range)

1075, 18, 5.5-33.8, 28.3 ± 30.8, 0-129

1138, 19, 5.5-38.8, 29.9 ± 32.6, 0-132

p = 0.446*

0.921

689, 11, 3-21.5, 18.1 ± 22.8, 0-99

623, 8, 2-20, 16.4 ± 20.3, 0-87

p = 0.420*

0.904

ADC x 10-3 s/mm2 (median, IQR, mean ± SD, range)

0.9, 0.9-1, 0.9 ± 0.2, 0-1.2

0.9, 0.9-1, 0.9 ± 0.2, 0-1.2

p = 0.350*

0.872

1, 0.9-1.1, 1 ± 0.2, 0-1.2

1, 0.9-1.1, 1 ± 0.2, 0-1.3

p = 0.448*

0.812

CBF ml/100g/min (median, IQR, mean ± SD, range)

131.6, 88.6-183.8, 137.5 ± 60.2, 0-295.9

139.3, 99.9-191.1, 141.8 ± 58.8, 0-295.9

p = 0.376**

0.844

124.3, 84.8-165.9, 124.6 ± 58.5, 0-263

105.5, 76.5-150, 115.1 ± 59.6, 0-270.8

p = 0.243**

0.848

CBV 100g/min (median, IQR, mean ± SD, range)

0.1, 0.1-0.2, 0.1 ± 0, 0-0.3

0.1, 0.1-0.2, 0.1 ± 0, 0-0.3

p = 0.500**

0.824

0.1, 0.1-0.2, 0.1 ± 0.1, 0-0.3

0.1, 0.1-0.1, 0.1 ± 0.1, 0-0.3

p = 0.181**

0.769

MTT seconds (median, IQR, mean ± SD, range)

8.3, 6.9-9, 8 ± 2.2, 0-12.1

8.1, 6.6-8.6, 7.8 ± 2.2, 0-12.1

p = 0.384**

0.836

8.4, 6.8-9.7, 8.2 ± 2.6, 0-15

8.4, 6.8-9.7, 81. ± 2.9, 0-15

p = 0.463**

0.828

  1. Values obtained by two different readers in non Gd-enhancing and T1-weighted isointense (C3) and non Gd-enhancing and T1-weighted hypointense (C4) T2-weighted hyperintense lesions from 38 patients with Relapsing-Remitting Multiple Sclerosis. ADC Apparent Diffusion Coefficient, CBF Cerebral Blood Flow, CBV Cerebral Blood Volume, MTT Mean Transit Time, First reader EG, Second reader EF; SD Standard deviation, IQR Interquartile range, *Mann-Whitney; **t-test