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Table 3 Number of focal lesions and ADC, CBF, CBV and MTT values in C3 and C4

From: A semi-automated measuring system of brain diffusion and perfusion magnetic resonance imaging abnormalities in patients with multiple sclerosis based on the integration of coregistration and tissue segmentation procedures

  C3 lesions C4 lesions
  First reader Second reader p value Kappa value First reader Second reader p value Kappa value
Lesion number (sum, median, IQR, mean ± SD, range) 1075, 18, 5.5-33.8, 28.3 ± 30.8, 0-129 1138, 19, 5.5-38.8, 29.9 ± 32.6, 0-132 p = 0.446* 0.921 689, 11, 3-21.5, 18.1 ± 22.8, 0-99 623, 8, 2-20, 16.4 ± 20.3, 0-87 p = 0.420* 0.904
ADC x 10-3 s/mm2 (median, IQR, mean ± SD, range) 0.9, 0.9-1, 0.9 ± 0.2, 0-1.2 0.9, 0.9-1, 0.9 ± 0.2, 0-1.2 p = 0.350* 0.872 1, 0.9-1.1, 1 ± 0.2, 0-1.2 1, 0.9-1.1, 1 ± 0.2, 0-1.3 p = 0.448* 0.812
CBF ml/100g/min (median, IQR, mean ± SD, range) 131.6, 88.6-183.8, 137.5 ± 60.2, 0-295.9 139.3, 99.9-191.1, 141.8 ± 58.8, 0-295.9 p = 0.376** 0.844 124.3, 84.8-165.9, 124.6 ± 58.5, 0-263 105.5, 76.5-150, 115.1 ± 59.6, 0-270.8 p = 0.243** 0.848
CBV 100g/min (median, IQR, mean ± SD, range) 0.1, 0.1-0.2, 0.1 ± 0, 0-0.3 0.1, 0.1-0.2, 0.1 ± 0, 0-0.3 p = 0.500** 0.824 0.1, 0.1-0.2, 0.1 ± 0.1, 0-0.3 0.1, 0.1-0.1, 0.1 ± 0.1, 0-0.3 p = 0.181** 0.769
MTT seconds (median, IQR, mean ± SD, range) 8.3, 6.9-9, 8 ± 2.2, 0-12.1 8.1, 6.6-8.6, 7.8 ± 2.2, 0-12.1 p = 0.384** 0.836 8.4, 6.8-9.7, 8.2 ± 2.6, 0-15 8.4, 6.8-9.7, 81. ± 2.9, 0-15 p = 0.463** 0.828
  1. Values obtained by two different readers in non Gd-enhancing and T1-weighted isointense (C3) and non Gd-enhancing and T1-weighted hypointense (C4) T2-weighted hyperintense lesions from 38 patients with Relapsing-Remitting Multiple Sclerosis. ADC Apparent Diffusion Coefficient, CBF Cerebral Blood Flow, CBV Cerebral Blood Volume, MTT Mean Transit Time, First reader EG, Second reader EF; SD Standard deviation, IQR Interquartile range, *Mann-Whitney; **t-test
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