A semi-automated measuring system of brain diffusion and perfusion magnetic resonance imaging abnormalities in patients with multiple sclerosis based on the integration of coregistration and tissue segmentation procedures

Table 3 Number of focal lesions and ADC, CBF, CBV and MTT values in C3 and C4

	C3 lesions				C4 lesions
	First reader	Second reader	p value	Kappa value	First reader	Second reader	p value	Kappa value
Lesion number (sum, median, IQR, mean ± SD, range)	1075, 18, 5.5-33.8, 28.3 ± 30.8, 0-129	1138, 19, 5.5-38.8, 29.9 ± 32.6, 0-132	p = 0.446*	0.921	689, 11, 3-21.5, 18.1 ± 22.8, 0-99	623, 8, 2-20, 16.4 ± 20.3, 0-87	p = 0.420*	0.904
ADC x 10-3 s/mm2 (median, IQR, mean ± SD, range)	0.9, 0.9-1, 0.9 ± 0.2, 0-1.2	0.9, 0.9-1, 0.9 ± 0.2, 0-1.2	p = 0.350*	0.872	1, 0.9-1.1, 1 ± 0.2, 0-1.2	1, 0.9-1.1, 1 ± 0.2, 0-1.3	p = 0.448*	0.812
CBF ml/100g/min (median, IQR, mean ± SD, range)	131.6, 88.6-183.8, 137.5 ± 60.2, 0-295.9	139.3, 99.9-191.1, 141.8 ± 58.8, 0-295.9	p = 0.376**	0.844	124.3, 84.8-165.9, 124.6 ± 58.5, 0-263	105.5, 76.5-150, 115.1 ± 59.6, 0-270.8	p = 0.243**	0.848
CBV 100g/min (median, IQR, mean ± SD, range)	0.1, 0.1-0.2, 0.1 ± 0, 0-0.3	0.1, 0.1-0.2, 0.1 ± 0, 0-0.3	p = 0.500**	0.824	0.1, 0.1-0.2, 0.1 ± 0.1, 0-0.3	0.1, 0.1-0.1, 0.1 ± 0.1, 0-0.3	p = 0.181**	0.769
MTT seconds (median, IQR, mean ± SD, range)	8.3, 6.9-9, 8 ± 2.2, 0-12.1	8.1, 6.6-8.6, 7.8 ± 2.2, 0-12.1	p = 0.384**	0.836	8.4, 6.8-9.7, 8.2 ± 2.6, 0-15	8.4, 6.8-9.7, 81. ± 2.9, 0-15	p = 0.463**	0.828

Values obtained by two different readers in non Gd-enhancing and T1-weighted isointense (C3) and non Gd-enhancing and T1-weighted hypointense (C4) T2-weighted hyperintense lesions from 38 patients with Relapsing-Remitting Multiple Sclerosis. ADC Apparent Diffusion Coefficient, CBF Cerebral Blood Flow, CBV Cerebral Blood Volume, MTT Mean Transit Time, First reader EG, Second reader EF; SD Standard deviation, IQR Interquartile range, *Mann-Whitney; **t-test

ISSN: 1471-2342