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Table 2 Number of focal lesions and ADC, CBF, CBV and MTT values in C1 and C2

From: A semi-automated measuring system of brain diffusion and perfusion magnetic resonance imaging abnormalities in patients with multiple sclerosis based on the integration of coregistration and tissue segmentation procedures

 

C1 lesions

C2 lesions

 

First reader

Second reader

p value*

Kappa value

First reader

Second reader

p value*

Kappa value

Lesion number (sum, median, IQR, mean ± SD, range)

4, 0, 0-0, 0.1 ± 0.3, 0-1

7, 0, 0-0, 0.2 ± 0.5, 0-2

p = 0.242

0.692

9, 0, 0-0, 0.3 ± 0.6, 0-2

12, 0, 0-0, 0.2 ± 0.7, 0-3

p = 0.148

0.614

ADC x 10-3 s/mm2 (median, IQR, mean ± SD, range)

0, 0-0, 0.1 ± 0.3, 0-0.9

0, 0-0, 0.1 ± 0.3, 0-0.9

p = 0.256

0.792

0, 0-0, 0.2 ± 0.4, 0-1.1

0, 0-0, 0.1 ± 0.3, 0-1.2

p = 0.146

0.721

CBF ml/100g/min (median, IQR, mean ± SD, range)

0, 0-0, 15.8 ± 50.2, 0-244.9

0, 0-0, 24 ± 59.3, 0-244.9

p = 0.2400

0.686

0, 0-0, 35.3 ± 76.2, 0-342.2

0, 0-0, 14.5 ± 39, 0-136.6

p = 0.108

0.450

CBV 100g/min (median, IQR, mean ± SD, range)

0, 0-0, 0 ± 0, 0-0.2

0, 0-0, 0 ± 0.1, 0-0.2

p = 0.248

0.742

0, 0-0, 0 ± 0.1, 0-0.4

0, 0-0, 0 ± 0.1, 0-0.3

p = 0.114

0.464

MTT seconds (median, IQR, mean ± SD, range)

0, 0-0, 0.8 ± 2.8, 0-15.3

0, 0-0, 1.1 ± 2.7, 0-11.2

p = 0.251

0.719

0, 0-0, 2 ± 3.8, 0-13.5

0, 0-0, 1.2 ± 3.3, 0-13.5

p = 0.136

0.673

  1. Values obtained by two different readers in Gd-enhancing and T1-weighted isointense (C1) and Gd-enhancing and T1-weighted hypointense (C2) T2-weighted hyperintense lesions from 38 patients with Relapsing-Remitting Multiple Sclerosis. ADC Apparent Diffusion Coefficient, CBF Cerebral Blood Flow, CBV Cerebral Blood Volume, MTT Mean Transit Time, First reader EG, Second reader EF, SD Standard deviation, IQR Interquartile range, *Mann-Whitney