A semi-automated measuring system of brain diffusion and perfusion magnetic resonance imaging abnormalities in patients with multiple sclerosis based on the integration of coregistration and tissue segmentation procedures

Table 2 Number of focal lesions and ADC, CBF, CBV and MTT values in C1 and C2

	C1 lesions				C2 lesions
	First reader	Second reader	p value*	Kappa value	First reader	Second reader	p value*	Kappa value
Lesion number (sum, median, IQR, mean ± SD, range)	4, 0, 0-0, 0.1 ± 0.3, 0-1	7, 0, 0-0, 0.2 ± 0.5, 0-2	p = 0.242	0.692	9, 0, 0-0, 0.3 ± 0.6, 0-2	12, 0, 0-0, 0.2 ± 0.7, 0-3	p = 0.148	0.614
ADC x 10-3 s/mm2 (median, IQR, mean ± SD, range)	0, 0-0, 0.1 ± 0.3, 0-0.9	0, 0-0, 0.1 ± 0.3, 0-0.9	p = 0.256	0.792	0, 0-0, 0.2 ± 0.4, 0-1.1	0, 0-0, 0.1 ± 0.3, 0-1.2	p = 0.146	0.721
CBF ml/100g/min (median, IQR, mean ± SD, range)	0, 0-0, 15.8 ± 50.2, 0-244.9	0, 0-0, 24 ± 59.3, 0-244.9	p = 0.2400	0.686	0, 0-0, 35.3 ± 76.2, 0-342.2	0, 0-0, 14.5 ± 39, 0-136.6	p = 0.108	0.450
CBV 100g/min (median, IQR, mean ± SD, range)	0, 0-0, 0 ± 0, 0-0.2	0, 0-0, 0 ± 0.1, 0-0.2	p = 0.248	0.742	0, 0-0, 0 ± 0.1, 0-0.4	0, 0-0, 0 ± 0.1, 0-0.3	p = 0.114	0.464
MTT seconds (median, IQR, mean ± SD, range)	0, 0-0, 0.8 ± 2.8, 0-15.3	0, 0-0, 1.1 ± 2.7, 0-11.2	p = 0.251	0.719	0, 0-0, 2 ± 3.8, 0-13.5	0, 0-0, 1.2 ± 3.3, 0-13.5	p = 0.136	0.673

Values obtained by two different readers in Gd-enhancing and T1-weighted isointense (C1) and Gd-enhancing and T1-weighted hypointense (C2) T2-weighted hyperintense lesions from 38 patients with Relapsing-Remitting Multiple Sclerosis. ADC Apparent Diffusion Coefficient, CBF Cerebral Blood Flow, CBV Cerebral Blood Volume, MTT Mean Transit Time, First reader EG, Second reader EF, SD Standard deviation, IQR Interquartile range, *Mann-Whitney

ISSN: 1471-2342