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Table 2 Lobar-level analysis of cortical tissue integrity.

From: Multimodal surface-based morphometry reveals diffuse cortical atrophy in traumatic brain injury.

Lobe Frontal Occipital Parietal Temporal
Hemisphere Left Right Left Right Left Right Left Right
Cortical GM
Thickness
-20.4%
5.4***
-18.3%
4.7***
-14.1%
2.7*
-15.4%
2.7*
-10.7%
2.1
-11.3%
2.2
-10.5%
2.6*
-12.3%
2.8*
Cortical GM
diffusivity
+15.6%
3.0*
+17.4%
3.4**
+13.1%
2.2
+15.9%
2.7*
+10.4%
1.3
+11.0%
1.6
+0.6%
0.1
+5.8%
1.3
Pericortical
WM anisotropy
-10.0%
2.3
-12.8%
2.8*
-9.9%
1.0
-9.3%
1.5
-9.9%
1.2
-7.9%
1.5
-4.9%
0.7
-4.0%
0.7
Pericortical WM
diffusivity
+6.5%
2.2
+10.6%
3.8**
+6.5%
1.1
+8.6%
2.0
+3.5%
0.7
+2.6%
0.6
-2.0%
-0.6
+1.8%
0.7
Joint abnormality (
Fisher's z)
4.98*** 5.54*** 2.27 2.89* 1.63 1.94 1.34 2.20
Joint abnormality
Replication
4.58*** 5.22*** 2.02 3.18* 1.45 1.74 1.04 1.94
  1. Percentage difference in the TBI patient with respect to mean values for the control group and the corresponding z-scores (boldface) are shown for cortical thickness, cortical mean diffusivity, and fractional anisotropy and mean diffusivity of pericortical white matter (2 mm below the gray-white boundary). Results are from the first imaging session. Asterisks (*, **, ***) indicate z-scores significant at the p < 0.05, 0.005, 0.0005 levels (z > 2.5, 3.3, 3.9, respectively), Bonferroni corrected for multiple comparisons across the four lobes and the two hemispheres. The bottom two rows show joint z-scores of all tissue metrics using Fisher's combined test for imaging sessions 1 and session 2.