Multimodal surface-based morphometry reveals diffuse cortical atrophy in traumatic brain injury.

BMC Medical Imaging

Table 2 Lobar-level analysis of cortical tissue integrity.

*Lobe*	Frontal		Occipital		Parietal		Temporal
*Hemisphere*	Left	Right	Left	Right	Left	Right	Left	Right
Cortical GM Thickness	-20.4% 5.4***	-18.3% 4.7***	-14.1% 2.7*	-15.4% 2.7*	-10.7% 2.1	-11.3% 2.2	-10.5% 2.6*	-12.3% 2.8*
Cortical GM diffusivity	+15.6% 3.0*	+17.4% 3.4**	+13.1% 2.2	+15.9% 2.7*	+10.4% 1.3	+11.0% 1.6	+0.6% 0.1	+5.8% 1.3
Pericortical WM anisotropy	-10.0% 2.3	-12.8% 2.8*	-9.9% 1.0	-9.3% 1.5	-9.9% 1.2	-7.9% 1.5	-4.9% 0.7	-4.0% 0.7
Pericortical WM diffusivity	+6.5% 2.2	+10.6% 3.8**	+6.5% 1.1	+8.6% 2.0	+3.5% 0.7	+2.6% 0.6	-2.0% -0.6	+1.8% 0.7
Joint abnormality ( Fisher's z)	4.98***	5.54***	2.27	2.89*	1.63	1.94	1.34	2.20
Joint abnormality Replication	4.58***	5.22***	2.02	3.18*	1.45	1.74	1.04	1.94

Percentage difference in the TBI patient with respect to mean values for the control group and the corresponding z-scores (boldface) are shown for cortical thickness, cortical mean diffusivity, and fractional anisotropy and mean diffusivity of pericortical white matter (2 mm below the gray-white boundary). Results are from the first imaging session. Asterisks (*, **, ***) indicate z-scores significant at the p < 0.05, 0.005, 0.0005 levels (z > 2.5, 3.3, 3.9, respectively), Bonferroni corrected for multiple comparisons across the four lobes and the two hemispheres. The bottom two rows show joint z-scores of all tissue metrics using Fisher's combined test for imaging sessions 1 and session 2.

ISSN: 1471-2342