TY - JOUR AU - Kiemeneij, F. AU - Serruys, P. W. AU - Macaya, C. AU - Rutsch, W. AU - Heyndrickx, G. AU - Albertsson, P. AU - Fajadet, J. AU - Legrand, V. AU - Materne, P. AU - Belardi, J. AU - Sigwart, U. AU - Colombo, A. AU - Goy, J. J. AU - Disco, C. M. AU - Morel, M. A. PY - 2001 DA - 2001// TI - Continued benefit of coronary stenting versus balloon angioplasty: five-year clinical follow-up of Benestent-I trial JO - J Am Coll Cardiol VL - 37 UR - https://doi.org/10.1016/S0735-1097(01)01207-4 DO - 10.1016/S0735-1097(01)01207-4 ID - Kiemeneij2001 ER - TY - JOUR AU - Morice, M. C. AU - Serruys, P. W. AU - Sousa, J. E. AU - Fajadet, J. AU - Ban, H. E. AU - Perin, M. AU - Colombo, A. AU - Schuler, G. AU - Barragan, P. AU - Guagliumi, G. AU - Molnar, F. AU - Falotico, R. PY - 2002 DA - 2002// TI - A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization JO - N Engl J Med VL - 346 UR - https://doi.org/10.1056/NEJMoa012843 DO - 10.1056/NEJMoa012843 ID - Morice2002 ER - TY - JOUR AU - Roiron, C. AU - Sanchez, P. AU - Bouzamondo, A. AU - Lechat, P. AU - Montalescot, G. PY - 2006 DA - 2006// TI - Drug eluting stents: an updated meta-analysis of randomised controlled trials JO - Heart VL - 92 UR - https://doi.org/10.1136/hrt.2005.061622 DO - 10.1136/hrt.2005.061622 ID - Roiron2006 ER - TY - JOUR AU - Johnson, L. W. AU - Krone, R. PY - 1993 DA - 1993// TI - Cardiac catheterization 1991: a report of the Registry of the Society for Cardiac Angiography and Interventions (SCA&I) JO - Cathet Cardiovasc Diagn VL - 28 UR - https://doi.org/10.1002/ccd.1810280305 DO - 10.1002/ccd.1810280305 ID - Johnson1993 ER - TY - JOUR AU - Scanlon, P. J. AU - Faxon, D. P. AU - Audet, A. M. AU - Carabello, B. AU - Dehmer, G. J. AU - Eagle, K. A. AU - Legako, R. D. AU - Leon, D. F. AU - Murray, J. A. AU - Nissen, S. E. AU - Pepine, C. J. AU - Watson, R. M. AU - Ritchie, J. L. AU - Gibbons, R. J. AU - Cheitlin, M. D. AU - Gardner, T. J. AU - Garson, A. AU - Russell, R. O. AU - Ryan, T. J. AU - Smith, S. C. PY - 1999 DA - 1999// TI - ACC/AHA guidelines for coronary angiography: executive summary and recommendations. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Coronary Angiography) developed in collaboration with the Society for Cardiac Angiography and Interventions JO - Circulation VL - 99 UR - https://doi.org/10.1161/01.CIR.99.17.2345 DO - 10.1161/01.CIR.99.17.2345 ID - Scanlon1999 ER - TY - JOUR AU - Wyman, R. M. AU - Safian, R. D. AU - Portway, V. AU - Skillman, J. J. AU - McKay, R. G. AU - Baim, D. S. PY - 1988 DA - 1988// TI - Current complications of diagnostic and therapeutic cardiac catheterization JO - J Am Coll Cardiol VL - 12 UR - https://doi.org/10.1016/S0735-1097(88)80002-0 DO - 10.1016/S0735-1097(88)80002-0 ID - Wyman1988 ER - TY - JOUR AU - Schuijf, J. D. AU - Bax, J. J. AU - Jukema, J. W. AU - Lamb, H. J. AU - Warda, H. M. AU - Vliegen, H. W. AU - de, R. A. AU - Wall, E. E. v. a. n. d. e. r. PY - 2004 DA - 2004// TI - Feasibility of assessment of coronary stent patency using 16-slice computed tomography JO - Am J Cardiol VL - 94 UR - https://doi.org/10.1016/j.amjcard.2004.04.057 DO - 10.1016/j.amjcard.2004.04.057 ID - Schuijf2004 ER - TY - JOUR AU - Cademartiri, F. AU - Mollet, N. AU - Lemos, P. A. AU - Pugliese, F. AU - Baks, T. AU - McFadden, E. P. AU - Krestin, G. P. AU - de Feyter, P. J. PY - 2005 DA - 2005// TI - Usefulness of multislice computed tomographic coronary angiography to assess in-stent restenosis JO - Am J Cardiol VL - 96 UR - https://doi.org/10.1016/j.amjcard.2005.05.023 DO - 10.1016/j.amjcard.2005.05.023 ID - Cademartiri2005 ER - TY - JOUR AU - Gilard, M. AU - Cornily, J. C. AU - Rioufol, G. AU - Finet, G. AU - Pennec, P. Y. AU - Mansourati, J. AU - Blanc, J. J. AU - Boschat, J. PY - 2005 DA - 2005// TI - Noninvasive assessment of left main coronary stent patency with 16-slice computed tomography JO - Am J Cardiol VL - 95 UR - https://doi.org/10.1016/j.amjcard.2004.08.073 DO - 10.1016/j.amjcard.2004.08.073 ID - Gilard2005 ER - TY - JOUR AU - Gaspar, T. AU - Halon, D. A. AU - Lewis, B. S. AU - Adawi, S. AU - Schliamser, J. E. AU - Rubinshtein, R. AU - Flugelman, M. Y. AU - Peled, N. PY - 2005 DA - 2005// TI - Diagnosis of coronary in-stent restenosis with multidetector row spiral computed tomography JO - J Am Coll Cardiol VL - 46 UR - https://doi.org/10.1016/j.jacc.2005.07.049 DO - 10.1016/j.jacc.2005.07.049 ID - Gaspar2005 ER - TY - CHAP AU - Chabbert, V. AU - Carrie, D. AU - Bennaceur, M. AU - Maupas, E. AU - Lauwers, V. AU - Mhem, M. AU - Lhermusier, T. AU - Elbaz, M. AU - Joffre, F. AU - Rousseau, H. AU - Puel, J. PY - 2006 DA - 2006// TI - Evaluation of in-stent restenosis in proximal coronary arteries with multidetector computed tomography (MDCT) BT - Eur Radiol ID - Chabbert2006 ER - TY - JOUR AU - Gilard, M. AU - Cornily, J. C. AU - Pennec, P. Y. AU - Le, G. G. AU - Nonent, M. AU - Mansourati, J. AU - Blanc, J. J. AU - Boschat, J. PY - 2006 DA - 2006// TI - Assessment of coronary artery stents by 16 slice computed tomography JO - Heart VL - 92 UR - https://doi.org/10.1136/hrt.2004.056010 DO - 10.1136/hrt.2004.056010 ID - Gilard2006 ER - TY - JOUR AU - Ohnuki, K. AU - Yoshida, S. AU - Ohta, M. AU - Shimizu, M. AU - Mochizuki, S. AU - Nishioka, M. AU - Sakuma, T. AU - Fukuda, K. AU - Ishizaki, M. AU - Hirakawa, E. AU - Andou, T. PY - 2006 DA - 2006// TI - New diagnostic technique in multi-slice computed tomography for in-stent restenosis: pixel count method JO - Int J Cardiol VL - 108 UR - https://doi.org/10.1016/j.ijcard.2005.05.013 DO - 10.1016/j.ijcard.2005.05.013 ID - Ohnuki2006 ER - TY - JOUR AU - Watanabe, M. AU - Uemura, S. AU - Iwama, H. AU - Okayama, S. AU - Takeda, Y. AU - Kawata, H. AU - Horii, M. AU - Nakajima, T. AU - Hirohashi, S. AU - Kichikawa, K. AU - Ookura, A. AU - Saito, Y. PY - 2006 DA - 2006// TI - Usefulness of 16-slice multislice spiral computed tomography for follow-up study of coronary stent implantation JO - Circ J VL - 70 UR - https://doi.org/10.1253/circj.70.691 DO - 10.1253/circj.70.691 ID - Watanabe2006 ER - TY - JOUR AU - Van Mieghem, C. A. AU - Cademartiri, F. AU - Mollet, N. R. AU - Malagutti, P. AU - Valgimigli, M. AU - Meijboom, W. B. AU - Pugliese, F. AU - McFadden, E. P. AU - Ligthart, J. AU - Runza, G. AU - Bruining, N. AU - Smits, P. C. AU - Regar, E. AU - Giessen, W. J. v. a. n. d. e. r. AU - Sianos, G. AU - van, D. R. AU - de, J. P. AU - Krestin, G. P. AU - Serruys, P. W. AU - de Feyter, P. J. PY - 2006 DA - 2006// TI - Multislice spiral computed tomography for the evaluation of stent patency after left main coronary artery stenting: a comparison with conventional coronary angiography and intravascular ultrasound JO - Circulation VL - 114 UR - https://doi.org/10.1161/CIRCULATIONAHA.105.608950 DO - 10.1161/CIRCULATIONAHA.105.608950 ID - Van Mieghem2006 ER - TY - JOUR AU - Rist, C. AU - von, Z. F. AU - Nikolaou, K. AU - Kirchin, M. A. AU - Wintersperger, B. J. AU - Johnson, T. R. AU - Knez, A. AU - Leber, A. W. AU - Reiser, M. F. AU - Becker, C. R. PY - 2006 DA - 2006// TI - Assessment of coronary artery stent patency and restenosis using 64-slice computed tomography JO - Acad Radiol VL - 13 UR - https://doi.org/10.1016/j.acra.2006.09.044 DO - 10.1016/j.acra.2006.09.044 ID - Rist2006 ER - TY - JOUR AU - Rixe, J. AU - Achenbach, S. AU - Ropers, D. AU - Baum, U. AU - Kuettner, A. AU - Ropers, U. AU - Bautz, W. AU - Daniel, W. G. AU - Anders, K. PY - 2006 DA - 2006// TI - Assessment of coronary artery stent restenosis by 64-slice multi-detector computed tomography JO - Eur Heart J VL - 27 UR - https://doi.org/10.1093/eurheartj/ehl303 DO - 10.1093/eurheartj/ehl303 ID - Rixe2006 ER - TY - JOUR AU - Kefer, J. M. AU - Coche, E. AU - Vanoverschelde, J. L. AU - Gerber, B. L. PY - 2007 DA - 2007// TI - Diagnostic accuracy of 16-slice multidetector-row CT for detection of in-stent restenosis vs detection of stenosis in nonstented coronary arteries JO - Eur Radiol VL - 17 UR - https://doi.org/10.1007/s00330-006-0291-5 DO - 10.1007/s00330-006-0291-5 ID - Kefer2007 ER - TY - JOUR AU - Ehara, M. AU - Kawai, M. AU - Surmely, J. F. AU - Matsubara, T. AU - Terashima, M. AU - Tsuchikane, E. AU - Kinoshita, Y. AU - Ito, T. AU - Takeda, Y. AU - Nasu, K. AU - Tanaka, N. AU - Murata, A. AU - Fujita, H. AU - Sato, K. AU - Kodama, A. AU - Katoh, O. AU - Suzuki, T. PY - 2007 DA - 2007// TI - Diagnostic accuracy of coronary in-stent restenosis using 64-slice computed tomography comparison with invasive coronary angiography JO - J Am Coll Cardiol VL - 49 UR - https://doi.org/10.1016/j.jacc.2006.10.065 DO - 10.1016/j.jacc.2006.10.065 ID - Ehara2007 ER - TY - JOUR AU - Oncel, D. AU - Oncel, G. AU - Karaca, M. PY - 2007 DA - 2007// TI - Coronary stent patency and in-stent restenosis: determination with 64-section multidetector CT coronary angiography–initial experience JO - Radiology VL - 242 UR - https://doi.org/10.1148/radiol.2422060065 DO - 10.1148/radiol.2422060065 ID - Oncel2007 ER - TY - JOUR AU - Maintz, D. AU - Juergens, K. U. AU - Wichter, T. AU - Grude, M. AU - Heindel, W. AU - Fischbach, R. PY - 2003 DA - 2003// TI - Imaging of coronary artery stents using multislice computed tomography: in vitro evaluation JO - Eur Radiol VL - 13 ID - Maintz2003 ER - TY - JOUR AU - Maintz, D. AU - Grude, M. AU - Fallenberg, E. M. AU - Heindel, W. AU - Fischbach, R. PY - 2003 DA - 2003// TI - Assessment of coronary arterial stents by multislice-CT angiography JO - Acta Radiol VL - 44 UR - https://doi.org/10.1046/j.1600-0455.2003.00130.x DO - 10.1046/j.1600-0455.2003.00130.x ID - Maintz2003 ER - TY - JOUR AU - Bossuyt, P. M. AU - Irwig, L. AU - Craig, J. AU - Glasziou, P. PY - 2006 DA - 2006// TI - Comparative accuracy: assessing new tests against existing diagnostic pathways JO - BMJ VL - 332 UR - https://doi.org/10.1136/bmj.332.7549.1089 DO - 10.1136/bmj.332.7549.1089 ID - Bossuyt2006 ER - TY - JOUR AU - Staunton, M. PY - 2007 DA - 2007// TI - Evidence-based radiology: steps 1 and 2–asking answerable questions and searching for evidence JO - Radiology VL - 242 UR - https://doi.org/10.1148/radiol.2421052135 DO - 10.1148/radiol.2421052135 ID - Staunton2007 ER - TY - JOUR AU - Haynes, R. B. AU - Wilczynski, N. L. PY - 2004 DA - 2004// TI - Optimal search strategies for retrieving scientifically strong studies of diagnosis from Medline: analytical survey JO - BMJ VL - 328 UR - https://doi.org/10.1136/bmj.38068.557998.EE DO - 10.1136/bmj.38068.557998.EE ID - Haynes2004 ER - TY - JOUR AU - Juni, P. AU - Witschi, A. AU - Bloch, R. AU - Egger, M. PY - 1999 DA - 1999// TI - The hazards of scoring the quality of clinical trials for meta-analysis JO - JAMA VL - 282 UR - https://doi.org/10.1001/jama.282.11.1054 DO - 10.1001/jama.282.11.1054 ID - Juni1999 ER - TY - JOUR AU - Whiting, P. AU - Rutjes, A. W. AU - Reitsma, J. B. AU - Bossuyt, P. M. AU - Kleijnen, J. PY - 2003 DA - 2003// TI - The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews JO - BMC Med Res Methodol VL - 3 UR - https://doi.org/10.1186/1471-2288-3-25 DO - 10.1186/1471-2288-3-25 ID - Whiting2003 ER - TY - JOUR AU - Gavaghan, D. J. AU - Moore, R. A. AU - McQuay, H. J. PY - 2000 DA - 2000// TI - An evaluation of homogeneity tests in meta-analyses in pain using simulations of individual patient data JO - Pain VL - 85 UR - https://doi.org/10.1016/S0304-3959(99)00302-4 DO - 10.1016/S0304-3959(99)00302-4 ID - Gavaghan2000 ER - TY - JOUR AU - Higgins, J. P. AU - Thompson, S. G. PY - 2002 DA - 2002// TI - Quantifying heterogeneity in a meta-analysis JO - Stat Med VL - 21 UR - https://doi.org/10.1002/sim.1186 DO - 10.1002/sim.1186 ID - Higgins2002 ER - TY - JOUR AU - Higgins, J. P. AU - Thompson, S. G. AU - Deeks, J. J. AU - Altman, D. G. PY - 2003 DA - 2003// TI - Measuring inconsistency in meta-analyses JO - BMJ VL - 327 UR - https://doi.org/10.1136/bmj.327.7414.557 DO - 10.1136/bmj.327.7414.557 ID - Higgins2003 ER - TY - JOUR AU - Deeks, J. J. AU - Macaskill, P. AU - Irwig, L. PY - 2005 DA - 2005// TI - The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed JO - J Clin Epidemiol VL - 58 UR - https://doi.org/10.1016/j.jclinepi.2005.01.016 DO - 10.1016/j.jclinepi.2005.01.016 ID - Deeks2005 ER - TY - JOUR AU - Egger, M. AU - Davey, S. G. AU - Schneider, M. AU - Minder, C. PY - 1997 DA - 1997// TI - Bias in meta-analysis detected by a simple, graphical test JO - BMJ VL - 315 UR - https://doi.org/10.1136/bmj.315.7109.629 DO - 10.1136/bmj.315.7109.629 ID - Egger1997 ER - TY - JOUR AU - Sterne, J. A. AU - Egger, M. AU - Smith, G. D. PY - 2001 DA - 2001// TI - Systematic reviews in health care: Investigating and dealing with publication and other biases in meta-analysis JO - BMJ VL - 323 UR - https://doi.org/10.1136/bmj.323.7304.101 DO - 10.1136/bmj.323.7304.101 ID - Sterne2001 ER - TY - JOUR AU - Littenberg, B. AU - Moses, L. E. PY - 1993 DA - 1993// TI - Estimating diagnostic accuracy from multiple conflicting reports: a new meta-analytic method JO - Med Decis Making VL - 13 UR - https://doi.org/10.1177/0272989X9301300408 DO - 10.1177/0272989X9301300408 ID - Littenberg1993 ER - TY - JOUR AU - Moses, L. E. AU - Shapiro, D. AU - Littenberg, B. PY - 1993 DA - 1993// TI - Combining independent studies of a diagnostic test into a summary ROC curve: data-analytic approaches and some additional considerations JO - Stat Med VL - 12 UR - https://doi.org/10.1002/sim.4780121403 DO - 10.1002/sim.4780121403 ID - Moses1993 ER - TY - JOUR AU - Reitsma, J. B. AU - Glas, A. S. AU - Rutjes, A. W. AU - Scholten, R. J. AU - Bossuyt, P. M. AU - Zwinderman, A. H. PY - 2005 DA - 2005// TI - Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews JO - J Clin Epidemiol VL - 58 UR - https://doi.org/10.1016/j.jclinepi.2005.02.022 DO - 10.1016/j.jclinepi.2005.02.022 ID - Reitsma2005 ER - TY - JOUR AU - Vanhoenacker, P. K. AU - Heijenbrok-Kal, M. H. AU - Van Heste, R. AU - Decramer, I. AU - Van Hoe, L. R. AU - Wijns, W. AU - Hunink, M. G. PY - 2007 DA - 2007// TI - Diagnostic performance of multidetector CT angiography for assessment of coronary artery disease: meta-analysis JO - Radiology VL - 244 UR - https://doi.org/10.1148/radiol.2442061218 DO - 10.1148/radiol.2442061218 ID - Vanhoenacker2007 ER - TY - JOUR AU - Zwinderman, A. H. AU - Bossuyt, P. M. PY - 2008 DA - 2008// TI - We should not pool diagnostic likelihood ratios in systematic reviews JO - Stat Med VL - 27 UR - https://doi.org/10.1002/sim.2992 DO - 10.1002/sim.2992 ID - Zwinderman2008 ER - TY - JOUR AU - Jaeschke, R. AU - Guyatt, G. H. AU - Sackett, D. L. PY - 1994 DA - 1994// TI - Users' guides to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? The Evidence-Based Medicine Working Group JO - JAMA VL - 271 UR - https://doi.org/10.1001/jama.1994.03510330081039 DO - 10.1001/jama.1994.03510330081039 ID - Jaeschke1994 ER - TY - JOUR AU - Dori, G. AU - Denekamp, Y. AU - Fishman, S. AU - Bitterman, H. PY - 2003 DA - 2003// TI - Exercise stress testing, myocardial perfusion imaging and stress echocardiography for detecting restenosis after successful percutaneous transluminal coronary angioplasty: a review of performance JO - J Intern Med VL - 253 UR - https://doi.org/10.1046/j.1365-2796.2003.01101.x DO - 10.1046/j.1365-2796.2003.01101.x ID - Dori2003 ER - TY - JOUR AU - Elhendy, A. AU - Tsutsui, J. M. AU - O'Leary, E. L. AU - Xie, F. AU - Majeed, F. AU - Porter, T. R. PY - 2006 DA - 2006// TI - Evaluation of restenosis and extent of coronary artery disease in patients with previous percutaneous coronary interventions by dobutamine stress real-time myocardial contrast perfusion imaging JO - Heart VL - 92 UR - https://doi.org/10.1136/hrt.2005.086140 DO - 10.1136/hrt.2005.086140 ID - Elhendy2006 ER - TY - JOUR AU - Elhendy, A. AU - Schinkel, A. F. AU - van Domberg, R. T. AU - Bax, J. J. AU - Valkema, R. AU - Poldermans, D. PY - 2006 DA - 2006// TI - Non-invasive diagnosis of in stent stenosis by stress 99 m technetium tetrofosmin myocardial perfusion imaging JO - Int J Cardiovasc Imaging VL - 22 UR - https://doi.org/10.1007/s10554-006-9087-6 DO - 10.1007/s10554-006-9087-6 ID - Elhendy2006 ER - TY - JOUR AU - Maintz, D. AU - Botnar, R. M. AU - Fischbach, R. AU - Heindel, W. AU - Manning, W. J. AU - Stuber, M. PY - 2002 DA - 2002// TI - Coronary magnetic resonance angiography for assessment of the stent lumen: a phantom study JO - J Cardiovasc Magn Reson VL - 4 UR - https://doi.org/10.1081/JCMR-120013303 DO - 10.1081/JCMR-120013303 ID - Maintz2002 ER - TY - JOUR AU - Sardanelli, F. AU - Zandrino, F. AU - Molinari, G. AU - Iozzelli, A. AU - Balbi, M. AU - Barsotti, A. PY - 2002 DA - 2002// TI - MR evaluation of coronary stents with navigator echo and breath-hold cine gradient-echo techniques JO - Eur Radiol VL - 12 UR - https://doi.org/10.1007/s003300101017 DO - 10.1007/s003300101017 ID - Sardanelli2002 ER - TY - JOUR AU - Spuentrup, E. AU - Ruebben, A. AU - Mahnken, A. AU - Stuber, M. AU - Kolker, C. AU - Nguyen, T. H. AU - Gunther, R. W. AU - Buecker, A. PY - 2005 DA - 2005// TI - Artifact-free coronary magnetic resonance angiography and coronary vessel wall imaging in the presence of a new, metallic, coronary magnetic resonance imaging stent JO - Circulation VL - 111 UR - https://doi.org/10.1161/01.CIR.0000156462.97532.8F DO - 10.1161/01.CIR.0000156462.97532.8F ID - Spuentrup2005 ER - TY - JOUR AU - Hausleiter, J. AU - Meyer, T. AU - Hadamitzky, M. AU - Huber, E. AU - Zankl, M. AU - Martinoff, S. AU - Kastrati, A. AU - Schomig, A. PY - 2006 DA - 2006// TI - Radiation dose estimates from cardiac multislice computed tomography in daily practice: impact of different scanning protocols on effective dose estimates JO - Circulation VL - 113 UR - https://doi.org/10.1161/CIRCULATIONAHA.105.602490 DO - 10.1161/CIRCULATIONAHA.105.602490 ID - Hausleiter2006 ER - TY - JOUR AU - Cademartiri, F. AU - Runza, G. AU - Mollet, N. R. AU - Luccichenti, G. AU - Belgrano, M. AU - Bartolotta, T. V. AU - Galia, M. AU - Midiri, M. AU - Pozzi, M. R. AU - Krestin, G. P. PY - 2005 DA - 2005// TI - Impact of intravascular enhancement, heart rate, and calcium score on diagnostic accuracy in multislice computed tomography coronary angiography JO - Radiol Med (Torino) VL - 110 ID - Cademartiri2005 ER - TY - JOUR AU - Cademartiri, F. AU - Mollet, N. R. AU - Runza, G. AU - Belgrano, M. AU - Malagutti, P. AU - Meijboom, B. W. AU - Midiri, M. AU - Feyter, P. J. AU - Krestin, G. P. PY - 2006 DA - 2006// TI - Diagnostic accuracy of multislice computed tomography coronary angiography is improved at low heart rates JO - Int J Cardiovasc Imaging VL - 22 UR - https://doi.org/10.1007/s10554-005-9010-6 DO - 10.1007/s10554-005-9010-6 ID - Cademartiri2006 ER - TY - STD TI - The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2342/8/14/prepub UR - http://www.biomedcentral.com/1471-2342/8/14/prepub ID - ref49 ER -