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Figure 7 | BMC Medical Imaging

Figure 7

From: Computer-assisted assessment of the Human Epidermal Growth Factor Receptor 2 immunohistochemical assay in imaged histologic sections using a membrane isolation algorithm and quantitative analysis of positive controls

Figure 7

ROC Curves comparing M n , Manual Scoring methods with Computer Assisted Image Analysis. These ROC curves report the sensitivity and specificity across all potential cutoff points for positive genetic amplification (≥ 2.3). In this plot, the quantitative use of controls (M n )is shown to significantly increase the area under the ROC curve when compared to tissue analysis alone (M p ). The arrow denotes a point on the M a curve where the false positive rate is significantly reduced compared to the 2+ point on the Manual Scoring curve. The AUC's of computer-assisted methods M n and M p are statistically similar to that of manual grading; only M a is statistically different.

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BMC Medical Imaging

ISSN: 1471-2342

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