ROC Curves comparing M
, Manual Scoring methods with Computer Assisted Image Analysis. These ROC curves report the sensitivity and specificity across all potential cutoff points for positive genetic amplification (≥ 2.3). In this plot, the quantitative use of controls (M
)is shown to significantly increase the area under the ROC curve when compared to tissue analysis alone (M
). The arrow denotes a point on the M
curve where the false positive rate is significantly reduced compared to the 2+ point on the Manual Scoring curve. The AUC's of computer-assisted methods M
are statistically similar to that of manual grading; only M
is statistically different.