Table 1 Guidelines for clinical disease score and motorical performance score.
From: In vivo study of experimental pneumococcal meningitis using magnetic resonance imaging
Motor Function | ||||
|---|---|---|---|---|
Grade | Movement | Front legs (Held by the tail, normally the front paws grip the edge of i.e. a table) | Hindlegs (Hind legs are placed below a table edge. Normal reaction is an immediate grip of the edge). | Climbing (Plate with an upward slope of 30 degrees. The rat will normally crawl upwards and grip the top edge). |
0 | Normal. | Both legs grip the table edge and is cabaple of "walking along the edge". | Normal. | Normal. |
1 | Movements slower. Can still be activated. | Both legs grips the edge. No movement. | Seeking to grip the table edge. | Does nor crawl upwards but spreads legs to hold on. |
2 | Prefers to stay in the same place. Nose is still active. Still climbing, Paws are seeking. | Only one leg grips the edge or no gripping. | Does not grip the edge. | Slides down. |
3 | Developing problems with controlling the limbs. Does not move. Tilting. Front paws sliding. | |||
4 | Paresis of one or more extremities. | |||
Clinical Appearance | ||||
Grade | Activity | Eyes | Fur | |
0 | Normal activity. | Normal eyes and surroundings. | Tended fur. | |
1 | Activity reduced, Turns easily if laid on the back. | Wet eyes. | Pilo-erection. | |
2 | Slow turning if laid on the back. | Haemorrhage around eyes. Scrathcing of eyes. | Pilo-erection and untended fur. | |
3 | Does not turn around. | |||
4 | Lying on the side. | |||