Table 1 Clinical and biochemical profile of 22 female subjects

number

6

10

2

1

1

2

age (years)

40 ± 16

48 ± 16

36 ± 15

41

64

40 ± 1

BMI (kg/m²)

26.4 ± 6.73

24.3 ± 2.07

33.9 ± 0.72

28.3

20.3

23.0 ± 0.08

Molecular genetic basis of disease

None

LMNA R482Q (all)

PPARG F388L (all)

None

LMNB2 R215G

BSCL2 frameshift (both)

diabetes

0/6

3/10

1/2

0/1

1/1

2/2

hypertension

1/6

5/10

2/2

1/1

1/1

1/1

dyslipidemia

0/6

10/10

2/2

1/1

1/1

1/1

total cholesterol (mM)

4.41 ± 0.54

4.76 ± 1.13

3.80 ± 0.43

5.37

3.63

4.08 ± 0.78

triglycerides (mM)

1.08 ± 0.63

2.62 ± 1.09

1.84 ± 1.27

6.29

2.82

2.13 ± 0.83

LDL cholesterol (mM)

2.36 ± 0.33

2.59 ± 1.11

2.42 ± 0.59

ND

1.50

2.09 ± 0.69

HDL cholesterol (mM)

1.56 ± 0.45

1.01 ± 0.29

0.88

0.50

0.85

1.04 ± 0.44

fasting blood glucose (mM)

4.71 ± 1.14

6.01 ± 1.74

8.35 ± 0.21

5.30

12.6

6.65 ± 1.34

insulin (uIU/mL)

13.8 ± 13.7

19.0 ± 14.6

29.5 ± 14.9

27.8

63.6

140 ± 130

apolipoprotein B (g/L)

0.71 ± 0.12

0.90 ± 0.18

ND

ND

0.75

0.99 ± 0.43

apolipoprotein A-I (g/L)

1.51 ± 0.38

1.25 ± 0.28

ND

ND

1.06

1.04 ± 0.21

systolic blood pressure (mm/Hg)

119 ± 19.2

127 ± 13.7

134 ± 8.49

126

108

113 ± 7

diastolic blood pressure (mm/Hg)

70 ± 11.7

73.5 ± 8.9

71.0 ± 8.5

82

56.0

75.0 ± 7.1

waist circumference (cm)

87.0 ± 19.2

87.5 ± 7.9

118 ± 17

107

118

77.5 ± 0.7