Table 2 The 25 included studies
Study | Total number Of patients | Suspected Condition | True +ve | False +ve | False -ve | True -ve | N | Sensitivity (95% CI) | Specificity (95% CI) | Likelihood ratio-positive (95% CI) | Likelihood ratio-negative (95% CI)* |
|---|---|---|---|---|---|---|---|---|---|---|---|
Adamek[9] | 86 | Abnormality | 42 | 1 | 5 | 12 | 60 | 0.89 (0.77, 0.95) | 0.92 (0.67, 0.99) | 11.62 (1.76, 76.57) | 0.12 (0.02, 0.76) |
Adamek | 81 | Malignancy | 22 | 0 | 5 | 33 | 60 | 0.81 (0.63, 0.92) | 1.00 (0.90, 1.00) | 54.64 (3.47, 861.18) | 0.20 (0.01, 3.14) |
Angulo[11] | 73 | Normal | 19 | 2 | 3 | 46 | 70 | 0.86 (0.67, 0.95) | 0.96 (0.86, 0.99) | 20.73 (5.28, 81.31) | 0.14 (0.04, 0.56) |
Angulo | 70 | dilitation CBD | 38 | 2 | 3 | 27 | 70 | 0.93 (0.81, 0.97) | 0.93 (0.78, 0.98) | 13.44 (3.52, 51.33) | 0.08 (0.02, 0.30) |
Angulo | 72 | Obstruction | 37 | 3 | 0 | 39 | 79 | 1.00 (0.91, 1.00) | 0.91 (0.76, 0.97) | 11.00 (3.74, 32.36) | 0.00 |
Angulo | 70 | Choledocholithiasis | 5 | 1 | 5 | 59 | 70 | 0.50 (0.24, 0.76) | 0.98 (0.91, 1.00) | 30.00 (3.90, 230.73) | 0.51 (0.07, 3.91) |
Angulo | 70 | PSC | 19 | 1 | 4 | 46 | 70 | 0.83 (0.63, 0.93) | 0.98 (0.89, 1.00) | 38.83 (5.53, 272.37) | 0.18 (0.03, 1.25) |
Barish[12] | 29 | Dilitation | 13 | 0 | 2 | 6 | 21 | 0.87 (0.62, 0.96) | 1.00 (0.61, 1.00) | 11.81 (0.81, 172.17) | 0.17 (0.01, 2.45) |
Calvo[13] | 61 | Choledocholithiasis | 29 | 2 | 3 | 10 | 44 | 0.91 (0.76, 0.97) | 0.83 (0.55, 0.95) | 5.44 (1.53, 19.36) | 0.11 (0.03, 0.40) |
Chan[14] | 47 | Choledocholithiasis | 18 | 4 | 1 | 22 | 45 | 0.95 (0.75, 0.99) | 0.85 (0.66, 0.94) | 6.16 (2.48, 15.26) | 0.06 (0.03, 0.15) |
Demartines[15] | 40 | Choledocholithiasis | 19 | 2 | 0 | 19 | 40 | 1.00 (0.83, 1.00) | 0.90 (0.71, 0.97) | 10.50 (2.81, 39.24) | 0.00 |
Dwerryhouse[16] | 40 | Choledocholithiasis | 7 | 2 | 1 | 28 | 38 | 0.88 (0.53, 0.98) | 0.93 (0.79, 0.98) | 13.13 (3.35, 51.36) | 0.1 (0.03, 0.52) |
Guibaud[18] | 79 | Obstruction | 72 | 0 | 7 | 47 | 126 | 0.91 (0.83, 0.96) | 1.00 (0.92, 1.00) | 87.00 (5.52, 1372.23) | 0.09 (0.01, 1.49) |
Guibaud | Choledocholithiasis | 26 | 2 | 6 | 92 | 126 | 0.81 (0.65, 0.91) | 0.98 (0.93, 0.99) | 38.19 (9.60, 151.97) | 0.19 (0.05, 0.76) | |
Guibaud | Malignancy | 12 | 2 | 2 | 110 | 126 | 0.86 (0.60, 0.96) | 0.98 (0.94, 1.00) | 48.00 (11.96, 192.72) | 0.15 (0.04, 0.58) | |
Holzknecht[20] | 61 | Choledocholithiasis | 12 | 3 | 2 | 46 | 63 | 0.86 (0.60, 0.96) | 0.94 (0.83, 0.98) | 14.00 (4.58, 42.78) | 0.15 (0.05, 0.47) |
Holzknecht | Dilatation | 32 | 2 | 2 | 26 | 62 | 0.94 (0.81, 0.98) | 0.93 (0.77, 0.98) | 13.18 (3.46, 50.23) | 0.06 (0.02, 0.24) | |
Holzknecht | Stenosis | 31 | 3 | 5 | 22 | 61 | 0.86 (0.71, 0.94) | 0.88 (0.70, 0.96) | 7.18 (2.46, 20.91) | 0.16 (0.05, 0.46) | |
Holzknecht | Overall | 43 | 3 | 4 | 12 | 62 | 0.91 (0.80, 0.97) | 0.80 (0.55, 0.93) | 4.57 (1.66, 12.63) | 0.11 (0.04, 0.29) | |
Laokpessi[21] | 101 | Choledocholithiasis | 105 | 0 | 8 | 34 | 147 | 0.93 (0.87, 0.96) | 1.00 (0.90, 1.00) | 64.78 (4.13, 1015.86) | 0.08 (0.00, 1.19) |
Lee[22] | 46 | Malignancy | 17 | 2 | 4 | 23 | 46 | 0.81 (0.60, 0.92) | 0.92 (0.75, 0.98) | 10.12 (2.64, 38.86) | 0.21 (0.05, 0.79) |
Lomanto[23] | 136 | Choledocholithiasis | 22 | 0 | 2 | 38 | 62 | 0.92 (0.74, 0.98) | 1.00 (0.91, 1.00) | 70.20 (4.46, 1105.97) | 0.10 (0.01, 1.60) |
Lomas[24] | 76 | Choledocholithiasis | 9 | 2 | 0 | 58 | 69 | 1.00 (0.70, 1.00) | 0.97 (0.89, 0.99) | 30.00 (7.68, 117.19) | 0.00 |
Lomas | Stricture | 19 | 1 | 0 | 49 | 69 | 1.00 (0.83, 1.00) | 0.98 (0.90, 1.00) | 50.00 (7.18, 348.04) | 0.00 | |
Macaulay[25] | 29 | Dilatation | 18 | 1 | 0 | 10 | 29 | 1.00 (0.82, 1.00) | 0.91 (0.62, 0.98) | 11.00 (1.70, 71.28) | 0.00 |
Regan[26] | 23 | Choledocholithiasis | 14 | 1 | 1 | 7 | 23 | 0.93 (0.70, 0.99) | 0.88 (0.53, 0.98) | 7.47 (1.19, 46.94) | 0.08 (0.01, 0.48) |
Reinhold[27] | 110 | Obstruction | 69 | 0 | 7 | 34 | 110 | 0.91 (0.82, 0.95) | 1.00 (0.90, 1.00) | 63.18 (4.03, 991.27) | 0.10 (0.01, 1.55) |
Reinhold | Choledocholithiasis | 27 | 3 | 3 | 77 | 110 | 0.90 (0.74, 0.97) | 0.96 (0.90, 0.99) | 24.00 (7.86, 73.31) | 0.10 (0.03, 0.32) | |
Soto 1996[28] | 46 | Dilatation | 26 | 1 | 1 | 16 | 44 | 0.96 (0.82, 0.99) | 0.94 (0.73, 0.99) | 16.37 (2.44, 109.77) | 0.04 (0.01, 0.26) |
Soto 2000[29] | 57 | Choledocholithiasis | 23 | 1 | 1 | 24 | 49 | 0.96 (0.80, 0.99) | 0.96 (0.80, 0.99) | 23.96 (3.50, 163.78) | 0.04 (0.01, 0.30) |
Soto 2000[30] | 51 | Choledocholithiasis | 25 | 0 | 1 | 25 | 51 | 0.96 (0.81, 0.99) | 1.00 (0.87, 1.00) | 49.11 (3.15, 765.62) | 0.06 (0.00, 0.88) |
Stiris[31] | 50 | Choledocholithiasis | 28 | 1 | 4 | 17 | 50 | 0.88 (0.72, 0.95) | 0.94 (0.74, 0.99) | 15.75 (2.33, 106.28) | 0.13 (0.02, 0.89) |
Sugiyama[32] | 159 | anamalous PBJ | 9 | 0 | 2 | 148 | 159 | 0.82 (0.52, 0.95) | 1.00 (0.97, 1.00) | 235.92 (14.60, 3811.82) | 0.21 (0.01, 3.38) |
Taylor[33] | 146 | Choledocholithiasis | 45 | 9 | 1 | 74 | 129 | 0.98 (0.89, 1.00) | 0.89 (0.81, 0.94) | 9.02 (4.86, 16.74) | 0.02 (0.01, 0.05) |
Taylor | Stricture | 12 | 1 | 0 | 118 | 131 | 1.00 (0.76, 1.00) | 0.99 (0.95, 1.00) | 118.00 (16.76, 830.78) | 0.00 | |
Textor[34] | 150 | PSC | 29 | 1 | 4 | 108 | 142 | 0.88 (0.73, 0.95) | 0.99 (0.95, 1.00) | 95.79 (13.56, 676.70) | 0.12 (0.02, 0.86) |
Varghese[35] | 191 | Choledocholithiasis | 31 | 3 | 3 | 154 | 191 | 0.91 (0.77, 0.97) | 0.98 (0.95, 0.99) | 47.72 (15.48, 147.06) | 0.09 (0.03, 0.28) |
Zidi[36] | 70 | Choledocholithiasis | 28 | 0 | 21 | 21 | 70 | 0.57 (0.43, 0.70) | 1.00 (0.85, 1.00) | 25.08 (1.60, 392.61) | 0.44 (0.03, 6.89) |