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Table 2 Clinical and radiological factors associated with survival and progression

From: Diffusion-weighted MRI characteristics of the cerebral metastasis to brain boundary predicts patient outcomes

Factor

Overall survival median/months

95% CI

Significance on univariate analysis

Progression free survival median/months

95% CI

Significance on univariate analysis

GPA score

      

 < 1.0

5.3

0.4 – 10.2

0.306

Not reached

 

0.936

 1.5-2

6.8

0 – 14.0

 

18.4

-

 2.5-3.0

9.3

8.0 – 10.6

 

17.8

6.1 – 29.4

 > 3.0

9.8

7.8 – 11.7

 

13.1

9.0 – 17.2

RPA class

      

 I

14.0

6.1 – 22.0

0.030*

17.7

14.6 – 20.9

0.636

 II

8.4

5.1 – 11.8

 

13.1

9.7 – 16.6

 

 III

2.0

0 – 6.2

 

Not reached

  

Primary cancer

     

(too many censored cases in each category for analysis)

 Lung non-small cell

9.2

2.0 – 19.8

0.061

Not reached

  

 Lung small cell

4.5

1.0 – 28.9

 

10.5

-

 

 Breast

10.4

0.9 – 21.2

 

9.2

5.6 – 12.9

 

 Colorectal

6.8

5.3 – 12.3

 

Not reached

  

 Melanoma

11.5

2.4 – 14.7

 

7.3

4.9 – 9.7

 

 Urological

4.0

1.1 – 9.6

 

Not reached

  

 Ovarian

11.2

4.7 – 30

 

17.8

-

 Unknown

5.6

1.5 – 22.8

 

18.4

-

Location

      

 Supratentorial

9.6

8.2 – 11.1

0.070

17.7

10.8 – 24.6

0.872

 Infratentorial

4.4

0 – 10.1

 

Not reached

  

Surgery

      

 Biopsy

5.9

0 – 16.4

0.091

   

 Resection

9.6

8.1 – 11.0

    

Adjuvant whole brain radiotherapy

      

 Yes

10.5

8.9 - 12

0.000*

17.7

10.9 – 24.6

0.000*

 No

2.4

1.5 – 3.3

 

Not reached

  

Adjuvant chemotherapy

      

 Yes

10.5

8.2 – 12.7

0.001*

15.7

10.7 – 20.6

0.240

 No

5.3

3.0 – 7.6

 

Not reached

  

Diffusion MR metrics

      

 ADCmin > 919 × 10-6 mm2/s

9.7

8.5 – 11.0

0.049*

18.4

13.2 – 23.6

0.087

 ADCmin < 919 × 10-6 mm2/s

6.2

3.7 – 8.8

 

11.3

8.4 – 14.3

 

 ADCmean > 1148 × 10-6 mm2/s

9.7

7.9 – 11.5

0.093

18.4

11.6 – 25.1

0.039*

 ADCmean < 1148 × 10-6 mm2/s

6.7

4.9 – 8.5

 

11.3

5.8 – 16.8

 

 ATC > 0.279

6.8

5.3 – 8.4

0.041*

11.3

8.2 – 14.4

0.072

 ATC < 0.279

11.2

8.3 – 14.0

 

Not reached

  

Standard MRI measures

      

 Diameter > 30 mm

6.7

2.4 – 11.0

0.246

13.1

9.7 – 16.6

0.551

 Diameter < 30 mm

9.6

8.8 – 10.4

 

17.8

14.7 – 20.1

 

 Volume > 8.9 cc

6.7

1.9 – 11.5

0.077

13.1

9.2 – 17.1

0.158

 Volume < 8.9 cc

9.6

8.8 – 10.3

 

17.8

13.7 – 21.8

 

 Solitary

8.42

5.3 – 11.5

0.101

15.7

10.3 – 21.0

0.673

 2 lesions

14.1

10.7- 17.6

 

11.3

0.85 – 21.8

 

 > 2 lesions

6.1

5.1 – 12.2

 

Not reached

  
  1. Log rank tests were applied to detect differences between categories with Wilcoxon modification (the Breslow chi square test) in cases where hazard did not appear to be proportional. In all comparisons *indicates p < 0.05.