Factor | Overall survival median/months | 95% CI | Significance on univariate analysis | Progression free survival median/months | 95% CI | Significance on univariate analysis |
---|---|---|---|---|---|---|
GPA score | ||||||
< 1.0 | 5.3 | 0.4 – 10.2 | 0.306 | Not reached | 0.936 | |
1.5-2 | 6.8 | 0 – 14.0 | 18.4 | - | ||
2.5-3.0 | 9.3 | 8.0 – 10.6 | 17.8 | 6.1 – 29.4 | ||
> 3.0 | 9.8 | 7.8 – 11.7 | 13.1 | 9.0 – 17.2 | ||
RPA class | ||||||
I | 14.0 | 6.1 – 22.0 | 0.030* | 17.7 | 14.6 – 20.9 | 0.636 |
II | 8.4 | 5.1 – 11.8 | 13.1 | 9.7 – 16.6 | ||
III | 2.0 | 0 – 6.2 | Not reached | |||
Primary cancer | (too many censored cases in each category for analysis) | |||||
Lung non-small cell | 9.2 | 2.0 – 19.8 | 0.061 | Not reached | ||
Lung small cell | 4.5 | 1.0 – 28.9 | 10.5 | - | ||
Breast | 10.4 | 0.9 – 21.2 | 9.2 | 5.6 – 12.9 | ||
Colorectal | 6.8 | 5.3 – 12.3 | Not reached | |||
Melanoma | 11.5 | 2.4 – 14.7 | 7.3 | 4.9 – 9.7 | ||
Urological | 4.0 | 1.1 – 9.6 | Not reached | |||
Ovarian | 11.2 | 4.7 – 30 | 17.8 | - | ||
Unknown | 5.6 | 1.5 – 22.8 | 18.4 | - | ||
Location | ||||||
Supratentorial | 9.6 | 8.2 – 11.1 | 0.070 | 17.7 | 10.8 – 24.6 | 0.872 |
Infratentorial | 4.4 | 0 – 10.1 | Not reached | |||
Surgery | ||||||
Biopsy | 5.9 | 0 – 16.4 | 0.091 | |||
Resection | 9.6 | 8.1 – 11.0 | ||||
Adjuvant whole brain radiotherapy | ||||||
Yes | 10.5 | 8.9 - 12 | 0.000* | 17.7 | 10.9 – 24.6 | 0.000* |
No | 2.4 | 1.5 – 3.3 | Not reached | |||
Adjuvant chemotherapy | ||||||
Yes | 10.5 | 8.2 – 12.7 | 0.001* | 15.7 | 10.7 – 20.6 | 0.240 |
No | 5.3 | 3.0 – 7.6 | Not reached | |||
Diffusion MR metrics | ||||||
ADCmin > 919 × 10-6 mm2/s | 9.7 | 8.5 – 11.0 | 0.049* | 18.4 | 13.2 – 23.6 | 0.087 |
ADCmin < 919 × 10-6 mm2/s | 6.2 | 3.7 – 8.8 | 11.3 | 8.4 – 14.3 | ||
ADCmean > 1148 × 10-6 mm2/s | 9.7 | 7.9 – 11.5 | 0.093 | 18.4 | 11.6 – 25.1 | 0.039* |
ADCmean < 1148 × 10-6 mm2/s | 6.7 | 4.9 – 8.5 | 11.3 | 5.8 – 16.8 | ||
ATC > 0.279 | 6.8 | 5.3 – 8.4 | 0.041* | 11.3 | 8.2 – 14.4 | 0.072 |
ATC < 0.279 | 11.2 | 8.3 – 14.0 | Not reached | |||
Standard MRI measures | ||||||
Diameter > 30 mm | 6.7 | 2.4 – 11.0 | 0.246 | 13.1 | 9.7 – 16.6 | 0.551 |
Diameter < 30 mm | 9.6 | 8.8 – 10.4 | 17.8 | 14.7 – 20.1 | ||
Volume > 8.9 cc | 6.7 | 1.9 – 11.5 | 0.077 | 13.1 | 9.2 – 17.1 | 0.158 |
Volume < 8.9 cc | 9.6 | 8.8 – 10.3 | 17.8 | 13.7 – 21.8 | ||
Solitary | 8.42 | 5.3 – 11.5 | 0.101 | 15.7 | 10.3 – 21.0 | 0.673 |
2 lesions | 14.1 | 10.7- 17.6 | 11.3 | 0.85 – 21.8 | ||
> 2 lesions | 6.1 | 5.1 – 12.2 | Not reached |