Figure 4From: Diffusion-weighted MRI characteristics of the cerebral metastasis to brain boundary predicts patient outcomes ADC of the metastasis predicts subsequent patient outcomes. Cases such as that in A. an enhancing lesion with hypo-intense DWI signal and higher than median ADC were compared to those such as B. an enhancing lesion but with hyper-intense DWI signal and corresponding low readings on ADC map. C. The largest group of metastases (n = 36) from a single primary - lung non-small cell carcinoma – were stratified into two groups by these readings of tumor ADC. Overall survival was significantly longer for cases with a high tumor ADCmean (10.5 months, CI 7.7 – 13.2) versus a low tumor ADCmean (5.8 months, CI 3.2 – 8.4, Log rank = 4.135, p = 0.042). D. For the 66 cases where gross total resection was performed, local recurrence in the brain occurred in 16. Metastases with a higher ADC showed significantly longer progression free survival, 18.4 months (95% CI 11.6 – 25.1) versus 11.3 months (95% 5.8 – 16.8) in those with a low ADCmean (Log rank test, Chi Square 4.263, p = 0.039).Back to article page