Brain region’s relative proximity as marker for Alzheimer’s disease based on structural MRI

BMC Medical Imaging

Table 5 The AUC values and corresponding ranksum p-values for classification of AD-NC, NC-MCI, and MCI-AD

(a) Baseline data, not adjusted
	NC-AD AUC	p −value	NC-MCI AUC	p −value	MCI-AD AUC	p −value
HP/ICV	0.878	<0.001	0.783	<0.001	0.635	<0.001
WB/ICV	0.724	<0.001	0.648	<0.001	0.648	<0.001
Surface all	0.818	<0.001	0.765	<0.001	0.740	<0.001
Surface func	0.877	<0.001	0.785	<0.001	0.766	<0.001
Surface potato	0.849	<0.001	0.785	<0.001	0.736	<0.001
Procrustes all	0.769	<0.001	0.679	<0.001	0.707	<0.001
Procrustes func	0.784	<0.001	0.656	<0.001	0.712	<0.001
Procrustes potato	0.752	<0.001	0.640	<0.001	0.705	<0.001
(b) Baseline whole brain, bl. volume adjusted
	NC-AD AUC	p −value	NC-MCI AUC	p −value	MCI-AD AUC	p −value
Surface all	0.752	<0.001	0.664	<0.001	0.574	0.024
Surface func	0.839	<0.001	0.695	<0.001	0.597	0.006
Surface potato	0.787	<0.001	0.705	<0.001	0.600	0.003
Procrustes all	0.678	<0.001	0.566	0.001	0.520	0.022
Procrustes func	0.689	<0.001	0.539	0.006	0.572	<0.001
Procrustes potato	0.650	<0.001	0.513	0.010	0.582	<0.001
(c) Baseline hippocampus volume, bl. volume adjusted
	NC-AD AUC	p −value	NC-MCI AUC	p −value	MCI-AD AUC	p −value
Surf all	0.639	0.001	0.608	<0.001	0.688	<0.001
Surf nfunc	0.739	<0.001	0.615	<0.001	0.729	<0.001
Surf potato	0.667	<0.001	0.622	<0.001	0.671	<0.001
Procrustes all	0.624	0.001	0.575	0.010	0.663	<0.001
Procrustes nfunc	0.631	<0.001	0.553	0.068	0.671	<0.001
Procrustes potato	0.574	0.041	0.529	0.328	0.658	<0.001

The last two markers were divided in three groups all, functional, and potato-shaped. 5(a) is the non-adjusted case, 5(b) and 5(c) is adjusted by whole brain fraction and hippocampus fraction, respectively. All markers were able to significantly distinguish the classes. Our markers were still significant after adjustment for the two volume scores, but AUC scores were in general lower than the non-adjusted scores. The surface connectivity score for the functional groups performed the best.

ISSN: 1471-2342