Figure 2
Video intensities curves. Predestruction and postdestruction video intensities curves for the control UCA (A–C) and the VEGFR2-targeted UCA (D–F). The average video intensity of predestruction and postdestruction sonograms was measured and the difference in video intensity between the predestruction and postdestruction ultrasonographic frames was calculated and expressed as video intensity difference (VID). This value provided a relative measure of the amount of targeted microbubbles retained by the tumor. Video Intensities curves of a normal thyroid parenchyma (A,D), adenoma (B,E) and a thyroid tumor (C,F). These images show a significant difference between retention of the control and VEGFR2-targeted UCAs in a thyroid tumor.