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Figure 1 | BMC Medical Imaging

Figure 1

From: Imaging of thyroid tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice

Figure 1

Targeted US of endothelial antigens in vessels of a tumor tissue. Endothelial cells of vessels (red) of tumor tissues expresses specific antigens. After intravenous administration targeted microbubbles (blue) float in vessels and remaining exclusively in the vascular compartment. Many of them bind to antigens of endothelial cells, whereas others remains in the vessel lumen freely circulating. After high-power destructive pulse, all microbubbles are destroyed (bound + circulating), following circulating microbubbles, that arrives from outside of scan plane, remain freely circulating for several seconds. On the top of the figure time/video intensity curve analysis before and after high-power destructive pulse and bottom a diagram representation of destructive methodology. Contrast intensity is the sum of the intensity from tissue, intensity from microbubbles not bound to receptors (circulating microbubbles), and intensity from microbubbles bound to receptors on endothelial cells. After digital subtraction of 300 predestruction frames from 300 postdestruction frames, resulting video intensity is due only to bound microbubbles.

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