Skip to main content
Figure 7 | BMC Medical Imaging

Figure 7

From: Lipomatous metaplasia identified in rabbits with reperfused myocardial infarction by 3.0 T magnetic resonance imaging and histopathology

Figure 7

Longitudinal evaluation of the changes of damaged myocardium (arrows), which progressively changed into scar tissue with moderate LM by in vivo and ex vivo cMRI in combination with postmortem histomorphology. Serial images of the midcardiac slice by T1WI (A1-C1), T2WI (A2-C2), DE-MRI (A3-C3) and Cine-MRI (A4-C4; A5-C5), respectively, taken at 48 hours (A1-A5), 2 months (B1-B5) and 9 months (C1-C5). Acute (48 hours) MI (A1-A5): The infarct appeared as isointense region on T1WI (A1); more extensive hyperintense region on T2WI (A2); hyperenhanced area including papillary muscle at the lateral wall on DE-MRI (A3); and isointense but hypokinetic region at the lateral wall on Cine-MRI (A4, A5). Chronic (2 months) MI (B1-B5): The lesion became almost isointense on both T1WI (B1) and T2WI (B2); moderately enhanced with blurred edge on DE-MRI (B3); and almost normal contraction and signals on the fat suppression Cine-MRI (B4, B5). Healed (9 months) MI (C1-C5): The lesion appeared slightly hyperintense on T1WI (C1) and T2WI (C2); no contrast enhancement on DE-MRI (C3); and partially lost signals on the fat suppression Cine-images, suggesting occurrence of little LM (C4, C5). Ex vivo T1WI without fat suppression (D1): there exist patching high signals on the later wall. Ex vivo T2WI with fat suppress (D2): the signal void area corresponded to the region with high signal on T1 WI, indicating the region of little LM. Photograph of macroscopic TTC section (E1): the clear distinction between normal myocardium and TTC negative region is observed. Photograph of macroscopic HE stained slide (E2): the region corresponding to TTC negative area appeared inhomogeneous, suggesting mixed scar tissues. Dashed square indicates where microscopy was focused. Photomicrograph of HE staining (E3) proves the presence of the adipose cells mixed with fibrotic scar (magnification, ×100). N: normal myocytes; S: scar tissue; LM: lipomatous metaplasia.

Back to article page