Figure 2

Graphical representation of percentage of activity in different organs with the time. Biodistribution study of IV injected In-111 oxine alone (A), In-111 labeled CTLs (B), In-111 labeled EPCs (C) and accumulation of In-111-CTLs and In-111-EPCs in glioma (D). In these graphs we included 1 and 2 hours san data along with 3, 24 and 72 hours. (A) In-111-oxine alone did not show significant change in organ distribution patterns from 1 to 72 hours. (B) Labeled CTLs showed 40% activity in lung at 2 hours, which dropped to 30% at 3 hours and further dropped after 24 and 72 hours, which indicates redistribution for CTLs from lung. Liver and spleen did not showed difference from 1 to 72 hour scans. (C) In-111 labeled EPCs showed lung associated activity at 1 hour scan but within 3 hours the activity was dropped by 68.4%, which indicates rapid redistribution of EPCs from the lung. Liver and spleen did not showed significant difference in activity from 3 to 72 hours. (D) Percentage of In-111 labeled CTLs and EPCs’ migration to tumor site and contralateral brain was determined in this graph at three time points (3, 24 and 72 hours). CTLs showed highest activity at 24 hours (0.8 ± 0.41%) compared to 3 and 72 hours. EPCs showed highest activity at 24 hours (2.77 ± 2.3%) compared to 3 and 72 hours.