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Table 2 Measurements by observer 2 (mean ± sd), inter-observer repeatability (Obs. 1: 2. meas.) and variation (N = 30) for FA and ADC (10 -3 mm 2 /s)

From: Repeatability and variation of region-of-interest methods using quantitative diffusion tensor MR imaging of the brain

  

Circular ROI

Freehand ROI

Region

Parameter

Mean ± SD

ICC

p

CV(%)

Mean ± SD

ICC

p

CV(%)

Basal pons

FA

0.705 ± 0.044

0.44

0.004*

8.6

0.621 ± 0.061

0.73

< 0.001*

9.2

 

ADC

0.726 ± 0.069

0.24

0.226

8.9

0.730 ± 0.080

0.01

0.487

8.4

Cerebral peduncle

FA

0.850 ± 0.035

0.62

0.006

4.9

0.788 ± 0.062

0.14

0.319

6.4

 

ADC

0.706 ± 0.048

0.56

0.018

7.0

0.772 ± 0.070

0.49

0.008

6.8

Internal capsule, post

FA

0.767 ± 0.046

0.67

< 0.001*

5.6

0.728 ± 0.036

0.80

< 0.001*

5.0

 

ADC

0.696 ± 0.034

0.63

0.001*

4.2

0.693 ± 0.021

0.84

< 0.001*

2.8

Corona radiata

FA

0.508 ± 0.038

0.54

0.023

8.6

0.515 ± 0.047

0.78

< 0.001*

9.0

 

ADC

0.648 ± 0.030

0.64

0.005

4.5

0.665 ± 0.025

0.93

< 0.001*

3.6

Centrum semiovale

FA

0.501 ± 0.067

0.64

0.004*

14.5

0.509 ± 0.051

0.47

0.007

9.9

 

ADC

0.700 ± 0.042

0.75

< 0.001*

6.0

0.693 ± 0.024

0.86

< 0.001*

3.3

Uncinate fasciculus

FA

0.529 ± 0.060

0.62

0.007

11.7

0.517 ± 0.050

0.74

< 0.001*

8.5

 

ADC

0.779 ± 0.036

0.55

0.018

4.4

0.768 ± 0.025

0.84

< 0.001*

3.7

Forceps minor

FA

0.545 ± 0.057

0.64

0.004*

12.0

0.499 ± 0.051

0.83

< 0.001*

9.5

 

ADC

0.762 ± 0.046

0.17

0.319

5.1

0.757 ± 0.029

0.88

< 0.001*

3.7

Ant corona radiata

FA

0.551 ± 0.073

0.84

< 0.001*

13.7

0.497 ± 0.040

0.86

< 0.001*

8.3

 

ADC

0.754 ± 0.029

0.45

0.060

3.8

0.748 ± 0.024

0.82

< 0.001*

3.5

CC genu

FA

0.836 ± 0.034

0.80

< 0.001*

4.2

0.785 ± 0.051

0.51

0.013

5.3

 

ADC

0.765 ± 0.044

0.80

< 0.001*

6.2

0.846 ± 0.069

0.37

0.012

7.3

CC body

FA

0.696 ± 0.057

0.39

0.066

6.7

0.654 ± 0.069

0.62

0.003*

9.8

 

ADC

0.821 ± 0.164

0.61

0.008

15

0.862 ± 0.114

0.65

0.001*

12.2

CC splenium

FA

0.864 ± 0.047

0.90

< 0.001*

5.6

0.838 ± 0.043

0.88

< 0.001*

5.2

 

ADC

0.717 ± 0.038

0.81

< 0.001*

5.4

0.739 ± 0.039

0.80

< 0.001*

5.5

  1. * = the statistical significance p < 0.05/11 with Bonferroni correction for 11 regions.
  2. ICC = intra-class correlation coefficient; CV = coefficient of variation.