Table 3 Quality of evidence of the difference between single reading (radiologist plus CAD) and double reading (two radiologists) related to cancer detection rate and recall rate in mammography screening (GRADE). Data from Gilbert et al.[71]
Outcome | Sample size (no. of studies) | True positive: Single reading + CAD (95% CI) | True positive: Double reading (95% CI) | Absolute difference (95%CI) | Quality of evidence | Rating based on study design/quality, indirectness, consistency, precision and publication bias** |
|---|---|---|---|---|---|---|
Cancer detection rate | 28,204 (1) | 0.702% | 0.706% | 0.004% | (⊕OOO) | Study quality –1 |
(0.6–0.8) | (0.6–0.8) | (NS*) | Insufficient | Indirectness–1 | ||
Recall rate | 28,204 (1) | 3,9% | 3,4% | 0,5% | (⊕OOO) | Study quality –1 |
(3,7–4,1) | (3,2–3,6) | (0,3–0,8) | Insufficient | Indirectness -1 One study –1 |