Table 2 Mean (± standard deviation) of (R)-[11C]verapamil parameter estimates for the different rat groups obtained using various modelling approaches (*** p < 0.001, ** p < 0.01, * p < 0.05., not significant (ns) p> 0.05)
Vehicle treated | Tariquidar treated | |||||||
|---|---|---|---|---|---|---|---|---|
Parameter estimates | Group 1: Saline | Group 2: Kainate | Group 1 vs Group 2 | Group 3: Saline | Group 4: Kainate | Group 3 vs Group 4 | Group 1 vs Group 3 | Group 2 vs Group 4 |
Model - Logan | ||||||||
K1 (mL· mL-1· min-1) | 0.06 (0.02) | 0.06 (0.02) | ns | 0.85 (0.16) | 0.74 (0.18) | ns | *** | *** |
Kp (mL· mL-1) | 1.04 (0.19) | 1.00 (0.13) | ns | 10. 9 (1.3) | 11.7 (1.3) | ns | *** | *** |
Model - 1T2K | ||||||||
K1 (mL· mL-1· min-1) | 0.06 (0.03) | 0.07 (0.03) | ns | 0.93 (0.19) | 0.66 (0.18) | *** | *** | *** |
k2 (min-1) | 0.08 (0.04) | 0.08 (0.04) | ns | 0.09 (0.02) | 0.06 (0.02) | ns | ns | ns |
Kp (mL· mL-1) | 0.81 (0.14) | 0.82 (0.12) | ns | 10.4 (1.0) | 10.6 (1.4) | ns | *** | *** |
Model -2T4K | ||||||||
K1 (mL· mL-1· min-1) | 0.07 (0.04) | 0.08 (0.04) | ns | 1.21(0.30) | 0.81 (0.27) | *** | *** | *** |
k2 (min-1) | 0.16 (0.15) | 0.24 (0.26) | ns | 0.73 (0.66) | 0.43 (0.35) | ns | * | ns |
k3 (min-1) | 0.11 (0.14) | 0.19 (0.30) | ns | 0.93 (0.75) | 0.84 (0.65) | ns | ** | * |
k4 (min-1) | 1.08 (1.56) | 0.49 (0.96) | ns | 0.20 (0.05) | 1.13 (1.82) | ns | ns | ns |
Kp (mL· mL-1) | 1.17 (0.65) | 1.12 (0.40) | ns | 11.0 (1.1) | 11.1 (1.5) | ns | *** | *** |
Model -2 comp PopPKa | ||||||||
K1 (mL· mL-1· min-1) | 0.10 (0.02) | 0.10 (0.02) | ns | 0.75 (0.14) | 0.62 (0.12) | *** | *** | *** |
k2 (min-1) | 0.25 (0.08) | 0.25 (0.08) | ns | 0.10 (0.04) | 0.08 (0.03) | * | *** | *** |
k3 (min-1) | 0.10 (0.03) | 0.10 (0.03) | ns | 0.04 (0.02) | 0.03 (0.01) | ns | *** | *** |
k4 (min-1) | 0.06 (0.02) | 0.06 (0.02) | ns | 0.06 (0.02) | 0.06 (0.02) | ns | ns | ns |
Kp (mL· mL-1) | 0.97 (0.21) | 0.97 (0.21) | ns | 11.6 (2.6) | 11.6 (2.6) | ns | *** | *** |