(R)-[11C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

Table 1 Number of animals (n) with weight at the time of PET scanning and injected doses of (R)-[11C]verapamil and 18FDG in the different treatment groups (mean ± s.d).

	Saline and vehicle treated	Kainate and vehicle treated	Saline and tariquidar treated	Kainate and tariquidar treated	All groups
n	10	11	10	11	42
Body weight (g)	327 ± 26	292 ± 33	326 ± 25	293 ± 24	308 ± 31
R-[¹¹C]verapamil (MBq)	22.3 ± 3.9	21.4 ± 4.8	22.1 ± 3.9	19.4 ± 5.1	20.8 ± 4.5
¹⁸FDG (MBq)	9.6 ± 2.1	8.5 ± 1.9	9.3 ± 1.6	9.1 ± 1.7	8.9 ± 1.8

Of the original 50 animals, 8 animals were discarded; 4 died as a result from the kainate treatment, 1 did not respond to kainate treatment, and 3 were excluded for technical reasons, such as movement in the scanner or extra vascular tracer injection.

ISSN: 1471-2342