Figure 4

Diagnostic plots for the final population model including both brain and plasma (R) -[ ¹¹ C]verapamil concentrations. All dots represent individual data points and the lines (upper panels) identity lines. Observed versus population and individual predictions are shown in the upper panels, respectively. Most of the data points are randomly distributed around the line of identity which indicates that the model describes the concentrations adequately. Absolute individual weighted residuals versus individual predictions and weighted residuals versus time are shown in the lower panels. Except for some outliers at early time points, most residuals are clustered around zero.