Renal interstitial fibrotic assessment using non-Gaussian diffusion kurtosis imaging in a rat model of hyperuricemia

Table 4 The pathological score of four groups in different time points(P)

The MOD of Masson trichrome staining in OS
	HUA	AP	AP + EM	P
1d	0.124 ± 0.005	0.119 ± 0.004	0.114 ± 0.006	0.123
5d	0.133 ± 0.008	0.124 ± 0.004	0.121 ± 0.006	0.112
9d	0.142 ± 0.007	0.134 ± 0.003	0.130 ± 0.004	0.054
The MOD of Masson trichrome staining in IS
	HUA	AP	AP + EM	P
1d	0.122 ± 0.006	0.117 ± 0.004	0.114 ± 0.003	0.195
5d	0.134 ± 0.004	0.132 ± 0.003	0.123 ± 0.003	0.019*
9d	0.142 ± 0.002	0.138 ± 0.002	0.132 ± 0.001	0.002*
The MOD of NF-κB immunostaining in OS
	HUA	AP	AP + EM	P
1d	0.128 ± 0.005	0.126 ± 0.007	0.121 ± 0.004	0.289
5d	0.144 ± 0.008	0.135 ± 0.006	0.128 ± 0.002	0.049*
9d	0.151 ± 0.003	0.136 ± 0.004	0.132 ± 0.003	0.002*
The MOD of NF-κB immunostaining in IS
	HUA	AP	AP + EM	P
1d	0.129 ± 0.004	0.123 ± 0.003	0.121 ± 0.002	0.050
5d	0.154 ± 0.006	0.145 ± 0.008	0.134 ± 0.005	0.033*
9d	0.155 ± 0.004	0.149 ± 0.008	0.141 ± 0.002	0.047*

Bold characteristics and *, were generated from comparisons among four groups at each time point by using one-way ANOVA
OS outer stripe of the outer medulla, IS inner stripe of the outer medulla, CON control, HUA hyperuricemia, AP allopurinol, AP + EM allopurinol + empagliflozin, MOD mean optical density

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