Renal interstitial fibrotic assessment using non-Gaussian diffusion kurtosis imaging in a rat model of hyperuricemia

Chen, Ping-Kang; Cheng, Zhong-Yuan; Wang, Ya-Lin; Xu, Bao-Jun; Yu, Zong-Chao; Li, Zhao-Xia; Gong, Shang-Ao; Zhang, Feng-Tao; Qian, Long; Cui, Wei; Feng, You-Zhen; Cai, Xiang-Ran

doi:10.1186/s12880-024-01259-8

Table 2 The DKI parameter's values of four groups in different time points (P)

From: Renal interstitial fibrotic assessment using non-Gaussian diffusion kurtosis imaging in a rat model of hyperuricemia

MKCO values
	CON	HUA	AP	AP + EM	P
base	0.857 ± 0.018	0.859 ± 0.020	0.857 ± 0.036	0.853 ± 0.020	0.452
1d	0.877 ± 0.015	0.864 ± 0.018	0.862 ± 0.012	0.867 ± 0.008	0.291
3d	0.862 ± 0.012	0.861 ± 0.010	0.842 ± 0.030	0.859 ± 0.007	0.172
5d	0.858 ± 0.032	0.840 ± 0.026	0.852 ± 0.022	0.858 ± 0.019	0.564
7d	0.852 ± 0.039	0.853 ± 0.033	0.858 ± 0.017	0.865 ± 0.023	0.859
9d	0.863 ± 0.025	0.866 ± 0.011	0.849 ± 0.016	0.845 ± 0.025	0.210
MKOS values
	CON	HUA	AP	AP + EM	P
base	0.760 ± 0.022	0.754 ± 0.011	0.769 ± 0.016	0.767 ± 0.010	0.337
1d	0.763 ± 0.015	0.758 ± 0.014	0.758 ± 0.010	0.753 ± 0.009	0.546
3d	0.763 ± 0.021	0.789 ± 0.018	0.775 ± 0.014	0.770 ± 0.011	0.074
5d	0.773 ± 0.016	0.820 ± 0.020	0.788 ± 0.023	0.778 ± 0.019	0.002*
7d	0.776 ± 0.022	0.821 ± 0.016	0.788 ± 0.017	0.785 ± 0.021	0.003*
9d	0.773 ± 0.024	0.820 ± 0.018	0.787 ± 0.011	0.780 ± 0.017	0.001*
MKIS values
	CON	HUA	AP	AP + EM	P
base	0.640 ± 0.035	0.657 ± 0.023	0.647 ± 0.021	0.653 ± 0.019	0.679
1d	0.658 ± 0.028	0.675 ± 0.023	0.658 ± 0.008	0.658 ± 0.019	0.437
3d	0.660 ± 0.021	0.737 ± 0.040	0.682 ± 0.024	0.670 ± 0.013	< 0.001*
5d	0.667 ± 0.029	0.776 ± 0.027	0.683 ± 0.019	0.673 ± 0.016	< 0.001*
7d	0.678 ± 0.025	0.789 ± 0.026	0.688 ± 0.012	0.681 ± 0.013	< 0.001*
9d	0.687 ± 0.029	0.787 ± 0.030	0.699 ± 0.009	0.693 ± 0.0.13	< 0.001*
FACO values
	CON	HUA	AP	AP + EM	P
base	0.263 ± 0.022	0.272 ± 0.015	0.270 ± 0.017	0.273 ± 0.021	0.802
1d	0.269 ± 0.011	0.264 ± 0.009	0.264 ± 0.015	0.264 ± 0.011	0.875
3d	0.283 ± 0.012	0.273 ± 0.010	0.275 ± 0.014	0.280 ± 0.013	0.462
5d	0.278 ± 0.0.13	0.270 ± 0.016	0.268 ± 0.018	0.272 ± 0.009	0.638
7d	0.280 ± 0.015	0.280 ± 0.007	0.275 ± 0.013	0.275 ± 0.008	0.810
9d	0.278 ± 0.014	0.266 ± 0.016	0.269 ± 0.011	0.264 ± 0.012	0.293
FAOS values
	CON	HUA	AP	AP + EM	P
base	0.444 ± 0.015	0.448 ± 0.021	0.450 ± 0.039	0.455 ± 0.033	0.925
1d	0.463 ± 0.021	0.463 ± 0.034	0.459 ± 0.024	0.461 ± 0.022	0.987
3d	0.470 ± 0.014	0.448 ± 0.029	0.455 ± 0.024	0.461 ± 0.017	0.371
5d	0.467 ± 0.030	0.440 ± 0.024	0.450 ± 0.033	0.462 ± 0.028	0.404
7d	0.470 ± 0.013	0.447 ± 0.041	0.450 ± 0.030	0.457 ± 0.031	0.565
9d	0.471 ± 0.006	0.448 ± 0.043	0.457 ± 0.028	0.462 ± 0.022	0.553
FAIS values
	CON	HUA	AP	AP + EM	P
base	0.748 ± 0.020	0.733 ± 0.021	0.733 ± 0.015	0.730 ± 0.011	0.316
1d	0.757 ± 0.014	0.740 ± 0.018	0.745 ± 0.025	0.739 ± 0.023	0.443
3d	0.751 ± 0.032	0.698 ± 0.035	0.723 ± 0.032	0.740 ± 0.030	0.053
5d	0.760 ± 0.016	0.669 ± 0.027	0.732 ± 0.034	0.740 ± 0.017	< 0.001*
7d	0.763 ± 0.026	0.643 ± 0.023	0.750 ± 0.030	0.755 ± 0.029	< 0.001*
9d	0.763 ± 0.014	0.644 ± 0.024	0.752 ± 0.011	0.757 ± 0.012	< 0.001*
MDCO values (× 10⁻³mm²/s)
	CON	HUA	AP	AP + EM	P
base	3.163 ± 0.118	3.240 ± 0.404	3.468 ± 0.258	3.327 ± 0.371	0.382
1d	2.593 ± 0.247	2.772 ± 0.302	2.708 ± 0.309	2.397 ± 0.378	0.206
3d	3.147 ± 0.422	2.927 ± 0.289	3.078 ± 0.594	2.910 ± 0.358	0.732
5d	2.635 ± 0.315	3.107 ± 0.452	2.652 ± 0.531	2.687 ± 0.377	0.204
7d	2.815 ± 0.685	3.115 ± 0.485	2.502 ± 0.097	2.680 ± 0.687	0.285
9d	3.170 ± 0.447	3.192 ± 0.281	2.840 ± 0.329	3.262 ± 0.416	0.242
MDOS values (× 10⁻³mm²/s)
	CON	HUA	AP	AP + EM	P
base	2.735 ± 0.222	2.608 ± 0.447	2.751 ± 0.237	2.666 ± 0.352	0.865
1d	2.766 ± 0.121	2.811 ± 0.161	2.784 ± 0.258	2.760 ± 0.235	0.972
3d	2.723 ± 0.227	2.239 ± 0.414	2.637 ± 0.328	2.661 ± 0.226	0.052
5d	2.770 ± 0.262	1.970 ± 0.318	2.428 ± 0.436	2.503 ± 0.378	0.008*
7d	2.781 ± 0.385	1.859 ± 0.413	2.362 ± 0.342	2.517 ± 0.311	0.002*
9d	2.790 ± 0.292	1.849 ± 0.460	2.349 ± 0.249	2.463 ± 0.286	0.001*
MDIS values(× 10⁻³mm²/s)
	CON	HUA	AP	AP + EM	P
base	2.628 ± 0.183	2.660 ± 0.213	2.567 ± 0.296	2.642 ± 0.624	0.975
1d	2.607 ± 0.121	2.332 ± 0.401	2.375 ± 0.173	2.333 ± 0.196	0.198
3d	2.605 ± 0.463	2.194 ± 0.306	2.307 ± 0.330	2.333 ± 0.658	0.479
5d	2.615 ± 0.229	2.287 ± 0.401	2.357 ± 0.266	2.444 ± 0.315	0.316
7d	2.716 ± 0.132	2.278 ± 0.421	2.456 ± 0.684	2.580 ± 0.370	0.396
9d	2.784 ± 0.194	2.321 ± 0.341	2.468 ± 0.427	2.705 ± 0.650	0.262

Bold characteristics and * were generated from comparisons between the four groups at each time point using one-way ANOVA
CO cortex, OS outer stripe of the outer medulla, IS inner stripe of the outer medulla, MK mean kurtosis, MD mean diffusivity, FA fractional anisotropy, CON control, HUA hyperuricemia, AP allopurinol, AP + EM allopurinol + empagliflozin, base basement

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