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Table 2 Clinicopathologic characteristics of patients and hepatic observations

From: Threshold growth has a limited role in differentiating hepatocellular carcinoma from other focal hepatic lesions

Characteristic

Value (%)

Patient (n = 379)

 Mean age (years)a

58.1 ± 10.4

 Sex, male/female

265/114

 Cirrhosis (%)

314 (82.8%)

Cause of liver disease (%)

 Hepatitis B virus

301 (79.4)

 Hepatitis C virus

38 (10.0)

 Alcohol consumption

9 (2.4)

 Autoimmune disorders

4 (1.1)

 NASH

1 (0.3)

 Hepatitis B and C virus

6 (1.6)

 Cirrhosis of unknown cause

20 (5.3)

Number of observations per patient (%)

 1

341 (90.0)

 2

29 (7.7)

 3

9 (2.4)

Observation (n = 426)

 Size (mm)

  Over allb

27 (16–52)

  HCCa

34.7 ± 27.3

  Non-HCC malignancyb

45 (27–66)

  Benign lesionb

22 (14–44)

 Final diagnosis (%)

  HCC

250 (58.7)

  Non-HCC malignancy

88 (20.7)

  ICC

41 (9.6)

  CHC

13 (3.1)

  Metastasis

23 (5.4)

  Sarcomatoid carcinoma

6 (1.4)

  Cystadenocarcinoma

3 (0.7)

  Neuroendocrine carcinoma

1 (0.2)

  Haemangiosarcoma

1 (0.2)

  Benign lesion

88 (20.7)

  Haemangioma

16 (3.8)

  DN

34 (8.0)

  RN

11 (2.6)

  FNH

9 (2.1)

  Adenoma or adenomatoid hyperplasia

6 (1.4)

  Abscess

4 (0.9)

  Angiomyolipoma

2 (0.5)

  Epithelioid angiomyolipoma

3 (0.7)

  Inflammatory nodule

1 (0.2)

  Lipomyoma

1(0.2)

  Ematoma

1 (0.2)

Standard reference of diagnosis (%)

  Surgical pathology

199 (46.7)

  Biopsy pathology

227 (53.3)

  1. Unless stated otherwise, data are presented as the number of patients or observations with the percentage in parentheses. aData are presented as the mean ± standard deviation; bData are presented as the median (interquartile range). NASHNonalcoholic steatohepatitis, HCC Hepatocellular carcinoma, ICC Intrahepatic cholangiocarcinoma, CHC Combined hepatocellular cholangiocarcinoma, DN Dysplastic nodule, RN Regenerative nodule, FNH Focal nodular hyperplasia